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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 144 - 149 (6page)
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Ceramides are the major sphingolipid metabolites involved in cell survival and apoptosis. When HepG2 hepatoma cells were treated with celecoxib, the expression of the genes in de novo sphingolipid biosynthesis and sphingomyelinase pathway was upregulated and cellular ceramide was elevated. In addition, celecoxib induced endoplasmic reticulum (ER) stress in a time-dependent manner. SPTLC2, a subunit of serine palmitoyltransferase, was overexpressed by adenovirus. Adenoviral overexpression of SPTLC2 (AdSPTLC2) decreased cell viability of HEK293 and HepG2 cells. In addition, AdSPTLC2 induced apoptosis via the caspase-dependent apoptotic pathway and elevated cellular ceramide, sphingoid bases, and dihydroceramide. However, overexpression of SPTLC2 did not induce ER stress. Collectively, celecoxib activates de novo sphingolipid biosynthesis and the combined effects of elevated ceramide and transcriptional activation of ER stress induce apoptosis. However, activation of de novo sphingolipid biosynthesis does not activate ER stress in hepatoma cells and is distinct from the celecoxib-mediated activation of ER stress.
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참고문헌 (23)
참고문헌 신청
Baran Y / 2007 / Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid
Brenner B / 1998 / Fas/CD95/ Apo-I activates the acidic sphingomyelinase via caspases / Cell Death Differ 5 : 29 ~ 37
Goldkorn T / 1998 / H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells / J Cell Sci 111 (Pt 21) : 3209
Grosch S / 2001 / COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib / FASEB J 15 : 2742 ~ 2744
Hannun YA / 2000 / Ceramide in the eukaryotic stress response / Trends Cell Biol 10 : 73 ~ 80
Brenner B / 1998 / Fas/CD95/ Apo-I activates the acidic sphingomyelinase via caspases / Cell Death Differ 5 : 29 ~ 37
Goldkorn T / 1998 / H2O2 acts on cellular membranes to generate ceramide signaling and initiate apoptosis in tracheobronchial epithelial cells / J Cell Sci 111 (Pt 21) : 3209
Grosch S / 2001 / COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib / FASEB J 15 : 2742 ~ 2744
Hannun YA / 2000 / Ceramide in the eukaryotic stress response / Trends Cell Biol 10 : 73 ~ 80
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