지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 1 - 12 (12page)
이용수
초록· 키워드
오류제보하기
Spinal cord injury after surgical repair of the thoracic or thoracoabdominal aorta is a devastating complication that is associated with pathological changes, including inflammation, edema, and nerve cell damage. Recently, microRNA (miRNA)-modulated control of spinal cord injury has been actively investigated. This study aims to clarify the regulatory effect of miR-214-mediated inhibition of Kcnk2 following spinal cord ischemia-reperfusion injury (SCII) and the possible underlying mechanisms. SCII was induced in rats by occluding the aortic arch followed by reperfusion. Gain-of-function and loss-of-function experiments were conducted to explore the modulatory effects of Foxd3, miR214 and Kcnk2 on PC12 cells under hypoxia/reoxygenation (H/R) conditions. MiR-214 and Kcnk2 were poorly expressed, while Foxd3 was highly expressed in the rat spinal cord tissues and H/R-treated PC12 cells. Kcnk2 overexpression enhanced the viability and inhibited the apoptosis of the H/R-treated PC12 cells. Notably, Foxd3 activated miR-214, and miR-214 targeted Kcnk2. In addition, upregulation of Kcnk2 or knockdown of Foxd3 promoted the cell viability and reduced the apoptosis of the H/R-treated PC12 cells. Overall, our study identified a novel mechanism of Foxd3/miR-214/Kcnk2 involving SCII, suggesting that either Foxd3 or miR-214 may be a novel target for the treatment of SCII.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
MiR-34a and miR-34b/c have distinct effects on the suppression of lung adenocarcinomas
Experimental and Molecular Medicine
2019 .01
-
MiR-34a, miR-21 and miR-23a as potential biomarkers for coronary artery disease: a pilot microarray study and confirmation in a 32 patient cohort
Experimental and Molecular Medicine
2015 .01
-
NMR hydrogen exchange study of miR156:miR156* duplexes
Journal of the Korean Magnetic Resonance Society
2019 .01
-
ANT2 shRNA downregulates miR-19a and miR-96 through the PI3K/Akt pathway and suppresses tumor growth in hepatocellular carcinoma cells
Experimental and Molecular Medicine
2016 .01
-
MicroRNA-375 is a therapeutic target for castration-resistant prostate cancer through the PTPN4/STAT3 axis
Experimental and Molecular Medicine
2022 .08
-
miR-30c regulates proliferation, apoptosis and differentiation via the Shh signaling pathway in P19 cells
Experimental and Molecular Medicine
2016 .01
-
miR-638 is a new biomarker for outcome prediction of non-small cell lung cancer patients receiving chemotherapy
Experimental and Molecular Medicine
2015 .01
-
microRNA-200a-3p increases 5-fluorouracil resistance by regulating dual specificity phosphatase 6 expression
Experimental and Molecular Medicine
2017 .01
-
Prefrontal cortex miR-29b-3p plays a key role in the antidepressant-like effect of ketamine in rats
Experimental and Molecular Medicine
2018 .01
-
microRNA-25 as a novel modulator of circadian Period2 gene oscillation
Experimental and Molecular Medicine
2020 .09
-
Multiplexed targeting of miRNA-210 in stem cell-derived extracellular vesicles promotes selective regeneration in ischemic hearts
Experimental and Molecular Medicine
2021 .04
-
MicroRNA-301b promotes cell proliferation and apoptosis resistance in triple-negative breast cancer by targeting CYLD
BMB Reports
2018 .01
-
MiR-371 promotes proliferation and metastasis in hepatocellular carcinoma by targeting PTEN
BMB Reports
2019 .01
-
MicroRNA-26a/b-5p promotes myocardial infarction-induced cell death by downregulating cytochrome c oxidase 5a
Experimental and Molecular Medicine
2021 .09
-
Plasma extracellular vesicle delivery of miR-210-3p by targeting ATG7 to promote sepsis-induced acute lung injury by regulating autophagy and activating inflammation
Experimental and Molecular Medicine
2021 .07
-
MiR-125a-5p ameliorates monocrotalineinduced pulmonary arterial hypertension by targeting the TGF-β1 and IL-6/STAT3 signaling pathways
Experimental and Molecular Medicine
2018 .01
-
MicroRNA-152-5p inhibits proliferation and migration and promotes apoptosis by regulating expression of Smad3 in human keloid fibroblasts
BMB Reports
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0