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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 312 - 317 (6page)
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초록· 키워드
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Hepatocellular carcinoma (HCC) is the leading cause of cancer-related mortality worldwide. MiR-371 has recently emerged as an important regulator in tumorigenesis, and may serve as a biomarker for malignant tumors. We transfected miR-371 or its inhibitor in two human HCC cell lines, then used 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, soft agar colony formation, and transwell migration assays to evaluate the effects on cell proliferation, migration, and invasion. We found that miR-371 was positively correlated with HCC metastasis and poor prognosis in the inflicted patients, and the high expression of miR-371 was promoted, whereas a low level of miR-371 depressed cell proliferation and invasion. We found PTEN to be a direct target of miR-371. The overexpression or knockdown of PTEN exhibited the opposite effects from those of miR-371 on cell proliferation and migration. Our study demonstrates that miR-371 promotes proliferation and metastasis in HCC by targeting PTEN.
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참고문헌 (23)
참고문헌 신청
Llovet JM / 2003 / Hepatocellular carcinoma / Lancet 362:1907~1917
Bandiera S / 2015 / miR-122-A key factor and therapeutic target in liver disease / J Hepatol 62:448~457
Wiemer EAC / 2007 / The role of microRNAs in cancer : No small matter / Eur J Cancer 43:1529~1544
Negrini M / 2011 / microRNA involvement in hepatocellular carcinoma / Anticancer Agents Med Chem 11:500~521
Ghasemi M / 2018 / Upregulation of miR-371-373cluster, a human embryonic stem cell specific microRNA cluster, in esophageal squamous cell carcinoma / J Cancer Res Ther 14:S132~S137
Bandiera S / 2015 / miR-122-A key factor and therapeutic target in liver disease / J Hepatol 62:448~457
Wiemer EAC / 2007 / The role of microRNAs in cancer : No small matter / Eur J Cancer 43:1529~1544
Negrini M / 2011 / microRNA involvement in hepatocellular carcinoma / Anticancer Agents Med Chem 11:500~521
Ghasemi M / 2018 / Upregulation of miR-371-373cluster, a human embryonic stem cell specific microRNA cluster, in esophageal squamous cell carcinoma / J Cancer Res Ther 14:S132~S137
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