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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 202 - 207 (6page)
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초록· 키워드
오류제보하기
Keloids are the most common pathological form of trauma healing, with features that seriously affect appearance and body function, are difficult to treat and have a high recurrence rate. Emerging evidence suggests that miRNAs are involved in a variety of pathological processes and play an important role in the process of fibrosis. In this study, we investigated the function and regulatory network of miR-152-5p in keloids. The miRNA miR-152-5p is frequently downregulated in keloid tissue and primary cells compared to normal skin tissue and fibroblasts. In addition, the downregulation of miR-152-5p is significantly associated with the proliferation, migration and apoptosis of keloid cells. Overexpression of miR-152-5p significantly inhibits the progression of fibrosis in keloids. Smad3 is a direct target of miR-152-5p, and knockdown of Smad3 also inhibits fibrosis progression, consistent with the overexpression of miR-152-5p. The interaction between miR-152-5p and Smad3 occurs through the Erk1/2 and Akt pathways and regulates collagen3 production. In summary, our study demonstrates that miR-152-5p/Smad3 regulatory pathways involved in fibrotic progression may be a potential therapeutic target of keloids.
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등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Patel PA / 2012 / Treatment outcomes for keloid scar management in the pediatric burn population / Burns 38:767~771
Carvalhaes SM / 2015 / Assesment of the treatment of earlobe keloids with triamcinolone injections, surgical resection, and local pressure / Rev Col Bras Cir 42:9~13
Jiang P / 2016 / Perioperative Interstitial High-Dose-Rate Brachytherapy for the Treatment of Recurrent Keloids : Feasibility and Early Results / Int J Radiat Oncol Biol Phys 94:532~536
Yi R / 2006 / Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs / Nature Genetics 38:356~362
Chau BN / 2011 / What goes up must come down : The Emerging Role of microrna in Fibrosis / Hepatology 53:4~6
Carvalhaes SM / 2015 / Assesment of the treatment of earlobe keloids with triamcinolone injections, surgical resection, and local pressure / Rev Col Bras Cir 42:9~13
Jiang P / 2016 / Perioperative Interstitial High-Dose-Rate Brachytherapy for the Treatment of Recurrent Keloids : Feasibility and Early Results / Int J Radiat Oncol Biol Phys 94:532~536
Yi R / 2006 / Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs / Nature Genetics 38:356~362
Chau BN / 2011 / What goes up must come down : The Emerging Role of microrna in Fibrosis / Hepatology 53:4~6
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