Effect of L-Carnitine Supplementation on Lipid Profiles of Patients with Liver Disease: A Systematic Review and Meta-Analysis

Amir Abbasnezhad; Amin Hasanavand; Ebrahim Falahi; Sara Kashkooli; Omid Asbaghi; Razieh Choghakhori

doi:10.3746/pnf.2020.25.2.124

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저자정보: Amir Abbasnezhad (Lorestan University of Medical Sciences) Amin Hasanavand (Lorestan University of Medical Sciences) Ebrahim Falahi (Lorestan University of Medical Sciences) Sara Kashkooli (Lorestan University of Medical Sciences) Omid Asbaghi (Lorestan University of Medical Sciences) Razieh Choghakhori (Lorestan University of Medical Sciences)

저널정보: 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.25 No.2

발행연도: 2020.6

수록면: 124 - 132 (9page)

DOI: 10.3746/pnf.2020.25.2.124

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Results of previous studies regarding the effect of L-carnitine on lipid profiles in the patients with liver diseases are contradictory. This meta-analysis was performed to assess the effect of L-carnitine on serum levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), and total cholesterol (TC) in overweight patients with liver diseases. A systematic search was carried out using the Web of Science, PubMed, Scopus, and Cochrane library databases to identify articles published before April 2019 investigating the effects of L-carnitine supplementation on patients with liver disease. There was no language or time limitation for the studies. A meta-analysis was carried out using both the random and fixed effects model where appropriate, and I2 index were used to evaluate heterogeneity. These results indicated that L-carnitine supplementation significantly reduces blood levels of TC and TG in patients with liver disease, whereas carnitine had no effect on the levels of HDL and LDL. The reducing effect of L-carnitine on both TC and TG was found following long-term carnitine supplementation (≥24 weeks), supplementation with doses less than or equal to 2,000 ㎎/d, and in patients with chronic hepatitis C. This meta-analysis indicates the beneficial effect of L-carnitine on TC and TG in overweight patients with liver disease, particularly patients with chronic hepatitis C, in both long-term and low doses.

#high-density lipoprotein #L-carnitine #low-density lipoprotein #total cholesterol #triglyceride

참고문헌 (30)

참고문헌 신청

Abbasnezhad A / 2019 / Effect of L-carnitine on liver enzymes and biochemical factors in hepatic encephalopathy : a systematic review and meta-analysis / J Gastroenterol Hepatol 34:2062~2070

Alavinejad P / 2016 / Evaluation of L-carnitine efficacy in the treatment of non-alcoholic fatty liver disease among diabetic patients : a randomized double blind pilot study / J Gastroenterol Hepatol Res 5:2191~2195

Alipour M / 2018 / The effects of catechins on related risk factors with type 2 diabetes : a review / Prog Nutr 20:12~20

Amani R / 2018 / Vitamin D3 induced decrease in IL-17 and malondialdehyde, and increase in IL-10 and total antioxidant capacity levels in patients with irritable bowel syndrome / Iran J Immunol 15:186~196

Asadi M / 2020 / The effect of L-carnitine supplementation on lipid profile and glycaemic control in adults with cardiovascular risk factors : a systematic review and meta-analysis of randomized controlled clinical trials / Clin Nutr 39:110~122

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