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자료유형
학술저널
저자정보
Ji Hyun Lee (Ministry of Food and Drug Safety) Ji Hyun Paek (Ministry of Food and Drug Safety) Han Na Park (Ministry of Food and Drug Safety) Seongsoo Park (Ministry of Food and Drug Safety) Hoil Kang (Ministry of Food and Drug Safety)
저널정보
한국분석과학회 분석과학 분석과학 제33권 제3호
발행연도
2020.6
수록면
125 - 133 (9page)

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Methylisothiazolinone (MIT) and chloromethylisothiazolinone (CMIT) cause allergic contact dermatitis and are banned cosmetics ingredients, except in rinse-off products. However, their presence has been detected in cosmetics. We report a UPLC–tandem MS/MS screening method for their simultaneous determination in cosmetics. To facilitate extraction from various matrices, pretreatment methods were developed for each sample type. The method was optimized through a series of assessments, including specificity, LOD, LOQ, linearity, recovery, stability, precision, and accuracy. The LODs and LOQs for MIT ranged from 0.054 and 0.163 μg mL−1 whereas those for CMIT ranged from 0.040 and 0.119 μg mL−1. The linear correlation coefficients (r2) were higher than 0.999. Relative standard deviations (RSDs) for both intra- and inter-day measurements ranged from 0.3 ~ 13.6 %. Recoveries at three different concentrations were within 87.9 ~ 118.9 %. The RSD for stability measurements of spiked samples was within 7 %. These results confirm the suitability of the developed method for the simultaneous quantitation of MIT and CMIT in cosmetics. Samples of 320 color cosmetics, including eyeshadows, solid lipsticks, liquid lipsticks, and nail polishes were analyzed using the developed method, and two of them were found to contain both MIT and CMIT and one of them was found to contain only MIT. This data and the method will aid the regulation of ingredients used in cosmetics.

목차

Abstract
1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
References

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UCI(KEPA) : I410-ECN-0101-2020-433-000657537