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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이 논문의 연구 히스토리 (8)
2019
Rapid determination and quantification of hair-growth compounds in adulterated products by ultra HPLC coupled to quadrupole-orbitrap MS
Ji Hyun Lee
,
Han Na Pa
,
k
외 6명
분석과학
2019.04
학술저널
Detection of phenobarbital adulteration in dietary supplements : simultaneous analysis of 16 sedative-hypnotics and sleep-inducers by ultra-high-performance liquid chromatography with UV detection (UPLC-UV) and quadruple Orbitrap mass spectrometry (Q-Orbitrap-MS)
Ji Hyun Lee
,
Ji Yeon Choi
,
Hanna Pa
외 8명
분석과학
2019.02
학술저널
2016
Analysis of erectile dysfunction drugs and their analogues in counterfeit drugs and herbal medicines by LC-ESI-MS/MS : Supplementary data
Ji Hyun Lee
,
Ji Hye Jeong
,
Hyoung-Joon Pa
외 5명
분석과학
2016.08
학술저널
Analysis of erectile dysfunction drugs and their analogues in counterfeit drugs and herbal medicines by LC-ESI-MS/MS
Ji Hyun Lee
,
Ji Hye Jeong
,
Hyoung-Joon Pa
외 5명
분석과학
2016.08
학술저널
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초록· 키워드
오류제보하기
The safety of food is occasionally questionable, as there have been some reports of products contaminated with illegal adulterants. In this study, the presence of 16 sedative-hypnotics and sleep inducers in dietary supplements was determined by ultra-high-performance liquid chromatography with UV detection (UPLC-UV) and quadruple Orbitrap mass spectrometry (Q-Orbitrap-MS). The UPLC method was validated, providing a linearity (R2) of more than 0.999, and LODs and LOQs that ranged from 0.2 to 0.5 and 0.6 to 1.5 μg mL−1, respectively. The repeatabilities were 0.2-8.4 % (intra-day) and 0.3-4.5 % (inter-day), and the accuracies were 89.0-117.0 % (intra-day) and 87.8-111.9 % (inter-day). The mean recoveries of the spiked samples ranged from 98.7 to 107.3 %. The relative standard deviation (%RSD) of the stability was less than 2.4 %. Using the developed method, one sedative-hypnotic compound, phenobarbital, was detected in one of the nineteen samples tested. In addition, the major characteristic fragment ions of each target compound were confirmed using Q-Orbitrap-MS for higher accuracy. Monitoring the presence of these 16 sedative-hypnotics and sleep inducers in dietary supplements should be pursued in the interest of human health, and the results of this study confirmed that the developed method has value for this application.
목차
Abstract
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
5. Conclusions
References
참고문헌 (17)
참고문헌 신청
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J. Liu, L. Xiao, X. Guan, Y. Xiong, T. Wang, and J. Li, Chin. J. Pharm. Anal., 31, 376-379 (2011).
P. Jin, Z. Wang, W. Wang, D. Zou, J. Ma, and X. Hu, Chin Pharm. J., 47, 462-466 (2012).
L. J. Greenfield, S. H. Zaman, M. L. Sutherland, S. C. Lummis, M. I. Niemeyer, E. A. Barnard, and R. L. Macdonald, Neuropharmacology, 42, 502-521 (2002).
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UCI(KEPA) : I410-ECN-0101-2019-433-000432215