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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 532 - 537 (6page)
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초록· 키워드
오류제보하기
ObjectiveaaElectroconvulsive therapy (ECT) is a reasonable option for intractable depression or schizophrenia, but a mechanism of action has not been established. One credible hypothesis is related to neural plasticity. Three genes (Oct4, Sox2, c-Myc) involved in the induction of induced pluripotent stem (iPS) cells are Wnt-target genes, which constitute a key gene group involved in neural plasticity through the TCF family. Klf4 is the other gene among Yamanaka’s four transcription factors, and increases in its expression are induced by stimulation of the canonical Wnt pathway.
MethodsaaWe compared the peripheral blood gene expression of the four iPS genes (Oct4, Sox2, c-Myc, and Klf4) before and after modified ECT (specifically ECT with general anesthesia) of patients with intractable depression (n=6) or schizophrenia (n=6). Using Thymatron ten times the total bilateral electrical stimulation was evoked.
ResultsaaBoth assessments of the symptoms demonstrated significant improvement after mECT stimulation. Expression of all four genes was confirmed to increase after initial stimulation. The gene expression levels after treatment were significantly different from the initial gene expression in all twelve cases at the following treatment stages: at the 3rd mECT for Oct4; at the 6th and 10th mECT for Sox2; and at the 3rd, 6th and 10th mECT for c-Myc.
ConclusionaaThese significant differences were not present after correction for multiple testing; however, our data have the potential to explain the molecular mechanisms of mECT from a unique perspective. Further studie should be conducted to clarify the pathophysiological involvement of iPS-inducing genes in ECT.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
/ / The wnt homepage
American Psychiatric Association / 2000 / Diagnostic and Statistical Manual of Mental Disorders, Text Revision (DSM-IV-TR) / American Psychiatric Association
Andersen P / 2003 / A prelude to long-term potentiation / Philos Trans R Soc Lond B Biol Sci 358 : 613 ~ 615
Andrade C / 2008 / Possible glutamatergic and lipid signalling mechanisms in ECT-induced retrograde amnesia: experimental evidence for involvement of COX-2, and review of lit
Bear MF / 1994 / Synaptic plasticity: LTP and LTD / Curr Opin Neurobiol 4 : 389 ~ 399
American Psychiatric Association / 2000 / Diagnostic and Statistical Manual of Mental Disorders, Text Revision (DSM-IV-TR) / American Psychiatric Association
Andersen P / 2003 / A prelude to long-term potentiation / Philos Trans R Soc Lond B Biol Sci 358 : 613 ~ 615
Andrade C / 2008 / Possible glutamatergic and lipid signalling mechanisms in ECT-induced retrograde amnesia: experimental evidence for involvement of COX-2, and review of lit
Bear MF / 1994 / Synaptic plasticity: LTP and LTD / Curr Opin Neurobiol 4 : 389 ~ 399
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