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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.8
- 수록면
- 445 - 450 (6page)
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Human infections due to the monkey malaria parasite Plasmodium knowlesi is increasingly being reported from most Southeast Asian countries specifically Malaysia. The parasite causes severe and fatal malaria thus there is a need for urgent measures for its control. In this study, the level of polymorphisms, haplotypes and natural selection of full-length pkmsp8 in 37 clinical samples from Malaysian Borneo along with 6 lab-adapted strains were investigated. Low levels of polymorphism were observed across the full-length gene, the double epidermal growth factor (EGF) domains were mostly conserved, and non-synonymous substitutions were absent. Evidence of strong negative selection pressure in the non-EGF regions were found indicating functional constrains acting at different domains. Phylogenetic haplotype network analysis identified shared haplotypes and indicated geographical clustering of samples originating from Peninsular Malaysia and Malaysian Borneo. This is the first study to genetically characterize the full-length msp8 gene from clinical isolates of P. knowlesi from Malaysia; however, further functional characterization would be useful for future rational vaccine design.
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참고문헌 (30)
참고문헌 신청
Ahmed MA / 2015 / Plasmodium knowlesi-an emerging pathogen / ISBT Sci Ser 10:134~140
Amir A / 2018 / Plasmodium knowlesi malaria : current research perspectives / Infect Drug Resist 11:1145~1155
Singh B / 2004 / A large focus of naturally acquired Plasmodium knowlesi infections in human beings / Lancet 363:1017~1024
Barber BE / 2013 / A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia : high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy / Clin Infect Dis 56:383~397
Barber BE / 2011 / Anstey NM : Plasmodium knowlesi malaria in children / Emerg Infect Dis 17:814~820
Amir A / 2018 / Plasmodium knowlesi malaria : current research perspectives / Infect Drug Resist 11:1145~1155
Singh B / 2004 / A large focus of naturally acquired Plasmodium knowlesi infections in human beings / Lancet 363:1017~1024
Barber BE / 2013 / A prospective comparative study of knowlesi, falciparum, and vivax malaria in Sabah, Malaysia : high proportion with severe disease from Plasmodium knowlesi and Plasmodium vivax but no mortality with early referral and artesunate therapy / Clin Infect Dis 56:383~397
Barber BE / 2011 / Anstey NM : Plasmodium knowlesi malaria in children / Emerg Infect Dis 17:814~820
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UCI(KEPA) : I410-ECN-0101-2020-513-000262660