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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 140 - 146 (7page)
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Objective Viral infections play an important role in the development of schizophrenia, inducing the faulty immunological responses and aberrant inflammation. IFN-γ-inducible protein 16 (IFI16) is an immunological DNA sensor against viral infections, triggering the inflammatory responses. In this study, we investigated an association between putative promoter single nucleotide polymorphisms (SNPs) and haplotypes of IFI16 and schizophrenia. Methods A total of 280 schizophrenia patients and 427 control subjects were recruited in this study. We genotyped three promoter SNPs (rs1465175, rs3754464, rs1417806) using direct sequencing. Associations of SNPs and haplotypes of IFI16 with schizophrenia were analyzed. The promoter activities on the haplotypes of IFI16 were measured. Results The T allele of rs1465175 and the C allele of rs1417806 were protectively associated with schizophrenia (p=0.021 on rs1465175; p=0.016 on rs1417806), whereas the G allele of rs3754464 was associated with an increased risk of schizophrenia (p=0.019). In haplotype analysis, a significant association between the GGA haplotype and schizophrenia was shown (p=0.013). Moreover, we found that the GGA haplotype elevated the promoter activity compared to the GAA haplotype, whereas the TAC haplotype reduced that. Conclusion The promoter SNPs and haplotypes of IFI16 may contribute to the susceptibility of schizophrenia, affecting the promoter activity of IFI16.
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참고문헌 (35)
참고문헌 신청
Brown AS / 2004 / Serologic evidence of prenatal influenza in the etiology of schizophrenia / Arch Gen Psychiatry 61:774~780
Ellman LM / 2010 / Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8 / Schizophr Res 121:46~54
Bechter K / 2013 / Updating the mild encephalitis hypothesis of schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 42:71~91
Prasad KM / 2013 / Antiherpes virus-specific treatment and cognition in schizophrenia : a test-of-concept randomized double-blind placebo-controlled trial / Schizophr Bull 39:857~866
Yolken RH / 2011 / Serological evidence of exposure to Herpes Simplex Virus type 1 is associated with cognitive deficits in the CATIE schizophrenia sample / Schizophr Res 128:61~65
Ellman LM / 2010 / Structural brain alterations in schizophrenia following fetal exposure to the inflammatory cytokine interleukin-8 / Schizophr Res 121:46~54
Bechter K / 2013 / Updating the mild encephalitis hypothesis of schizophrenia / Prog Neuropsychopharmacol Biol Psychiatry 42:71~91
Prasad KM / 2013 / Antiherpes virus-specific treatment and cognition in schizophrenia : a test-of-concept randomized double-blind placebo-controlled trial / Schizophr Bull 39:857~866
Yolken RH / 2011 / Serological evidence of exposure to Herpes Simplex Virus type 1 is associated with cognitive deficits in the CATIE schizophrenia sample / Schizophr Res 128:61~65
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