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자료유형
학술저널
저자정보
Hyunseok Kong (Sahmyook University) Sang Bum Kim (Sahmyook University)
저널정보
대한면역학회 Immune Network Immune Network Vol.22 No.5
발행연도
2022.10
수록면
17 - 40 (24page)

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Exosomes, which are well-known nanoscale extracellular vesicles, are multifunctional biomaterials derived from endosomes and perform various functions. The exosome is a critical material in cell-cell communication. In addition, it regulates the pathophysiological conditions of the tumor microenvironment in particular. In the tumor microenvironment, exosomes play a controversial role in supporting or killing cancer by conveying biomaterials derived from parent cells. Innate immunity is a crucial component of the host defense mechanism, as it prevents foreign substances, such as viruses and other microbes and tumorigenesis from invading the body. Early in the tumorigenesis process, the innate immunity explicitly recognizes the tumor via Ags and educates the adaptive immunity to eliminate it. Recent studies have revealed that exosomes regulate immunity in the tumor microenvironment. Tumor-derived exosomes regulate immunity against tumor progression and metastasis. Furthermore, tumor-derived exosomes regulate polarization, differentiation, proliferation, and activation of innate immune cells. Exosomes produced from innate immune cells can inhibit or support tumor progression and metastasis via immune cell activation and direct cancer inhibition. In this study, we investigated current knowledge regarding the communication between tumor-derived exosomes and innate immune cell-derived exosomes (from macrophages, dendritic cells, NK cells, and neutrophils) in the tumor microenvironment. In addition, we discussed the potential development of exosomal immunotherapy using native or engineered exosomes against cancer.

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ABSTRACT
INTRODUCTION
EXOSOME CHARACTERISTICS
EXOSOMAL COMMUNICATION BETWEEN THE TUMOR AND INNATE IMMUNE SYSTEM
THERAPEUTIC APPLICATIONS OF EXOSOMES
CONCLUSION
REFERENCES

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