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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 73 - 83 (11page)
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Foot-and-Mouth Disease (FMD) is a highly contagious trans-boundary viral disease caused by FMD vi-rus, which causes huge economic losses. FMDV infects cloven hoofed (two-toed) mammals such as cat-tle, sheep, goats, pigs and various wildlife species. To control the FMDV, it is necessary to understand the life cycle and the pathogenesis of FMDV in host. Especially, the protein-protein interaction between FMDV and host will help to understand the survival cycle of viruses in host cell and establish new therapeutic strategies. However, the computational approach for protein-protein interaction between FMDV and pig hosts have not been applied to studies of the onset mechanism of FMDV. In the present work, we have performed the prediction of the pig’s proteins which interact with FMDV based on RNA-Seq data, protein sequence, and structure information. After identifying the virus-host interaction, we looked for meaningful pathways and anticipated changes in the host caused by infection with FMDV. A total of 78 proteins of pig were predicted as interacting with FMDV. The 156 interactions include 94 interactions predicted by sequence-based method and the 62 interactions predicted by struc-ture-based method using domain information. The protein interaction network contained integrin as well as STYK1, VTCN1, IDO1, CDH3, SLA-DQB1, FER, and FGFR2 which were related to the up-regu-lation of inflammation and the down-regulation of cell adhesion and host defense systems such as mac-rophage and leukocytes. These results provide clues to the knowledge and mechanism of how FMDV affects the host cell.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
S Alexandersen / 2003 / The Pathogenesis and Diagnosis of Foot-and-Mouth Disease / Journal of Comparative Pathology 129(1):1~36
Baxt B. / 1990 / The effect of peptides containing the arginine-glycine-aspartic acid sequence on the adsorption of foot-and-mouth disease virus to tissue culture cells / Virus genes 4(1):73~83
Bindea G / 2009 / ClueGO : a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks / Bioinformatics(Oxford, England) 25(8):1091~1093
Grzegorz M Boratyn / 2012 / Domain enhanced lookup time accelerated BLAST / Biology Direct 7(1):12
Boutet E / 2016 / UniProtKB/Swiss-Prot, the Manually Annotated Section of the UniProt KnowledgeBase: How to Use the Entry View / Humana Press :23~54
Baxt B. / 1990 / The effect of peptides containing the arginine-glycine-aspartic acid sequence on the adsorption of foot-and-mouth disease virus to tissue culture cells / Virus genes 4(1):73~83
Bindea G / 2009 / ClueGO : a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks / Bioinformatics(Oxford, England) 25(8):1091~1093
Grzegorz M Boratyn / 2012 / Domain enhanced lookup time accelerated BLAST / Biology Direct 7(1):12
Boutet E / 2016 / UniProtKB/Swiss-Prot, the Manually Annotated Section of the UniProt KnowledgeBase: How to Use the Entry View / Humana Press :23~54
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