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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한백신학회 Clinical and Experimental Vaccine Research Clinical and Experimental Vaccine Research Vol.7 No.2
- 발행연도
- 2018.1
- 수록면
- 139 - 144 (6page)
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초록· 키워드
오류제보하기
Vaccination is considered a frequently used tool to prevent and control foot-and-mouth disease (FMD). However, the effectiveness of conventional FMD virus (FMDV) vaccines in pigs has been controversial because the massive prophylactic vaccination could not elicit proper immune response nor prevent the broad spread of FMD outbreak, mainly in pig farms, in South Korea during outbreaks of 2014. In addition, there has been little information on the efficacy of inactivated, high potency, multivalent, oil-based FMDV vaccine in pigs, because an evaluation of FMDV vaccines had been mainly carried out using cattle. In this study, we evaluated the genetic identification of commercial inactivated FMDV vaccine and monitored the immune responses in pigs under the field condition. Results implied that it contained three different serotypes with a high level of antigen payload. However, serological results showed low mean percentage of inhibition, and positive rate reached its peak at 6-week post-vaccination, indicating current FMDV vaccine need to improve for a prophylactic vaccination policy in pigs. Therefore, there is an imperative need to develop FMDV vaccine that can provide rapid and long-lasting protective immunity in pigs.
목차
등록된 정보가 없습니다.
참고문헌 (17)
참고문헌 신청
Grubman MJ / 2004 / Foot-and-mouth disease / Clin Microbiol Rev 17:465~493
Leon EA / 2012 / Foot-and-mouth disease in pigs: current epidemiological situation and control methods / Transbound Emerg Dis 59(Suppl 1):36~49
Lyons NA / 2016 / Challenges of generating and maintaining protective vaccine-induced immune responses for foot-and-mouth disease virus in pigs / Front Vet Sci 3:102
Park JH / 2014 / Reemergence of foot-and-mouth disease, South Korea, 2000-2011 / Emerg Infect Dis 20:2158~2161
Reid SM / 2002 / Detection of all seven serotypes of foot-and-mouth disease virus by real-time, fluorogenic reverse transcription polymerase chain reaction assay / J Virol Methods 105:67~80
Leon EA / 2012 / Foot-and-mouth disease in pigs: current epidemiological situation and control methods / Transbound Emerg Dis 59(Suppl 1):36~49
Lyons NA / 2016 / Challenges of generating and maintaining protective vaccine-induced immune responses for foot-and-mouth disease virus in pigs / Front Vet Sci 3:102
Park JH / 2014 / Reemergence of foot-and-mouth disease, South Korea, 2000-2011 / Emerg Infect Dis 20:2158~2161
Reid SM / 2002 / Detection of all seven serotypes of foot-and-mouth disease virus by real-time, fluorogenic reverse transcription polymerase chain reaction assay / J Virol Methods 105:67~80
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