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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제2호
- 발행연도
- 2019.1
- 수록면
- 250 - 260 (11page)
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초록· 키워드
오류제보하기
Objective: Dopamine plays a significant role in working memory by acting as a key neuromodulator between brain networks. Additionally, treatment of patients with schizophrenia using amisulpride, a pure dopamine class 2/3 receptor antagonist, improves their clinical symptoms with fewer side effects. We hypothesized that patients with schizophrenia treated with amisulpride and aripiprazole show increased working memory and glucose metabolism compared with those treated with cognitive behavioral therapy (CBT) and aripiprazole instead. Methods: Sixteen patients with schizophrenia (eight in the amisulpride group [aripiprazole+amisulpride] and eight in the CBT group [aripiprazole+CBT]) and 15 age- and sex-matched healthy control subjects were recruited for a 12-week-long prospective trial. An [18F]-fluorodeoxyglucose-positron emission tomography/computerized tomography scanner was used to acquire the images. Results: After 12 weeks of treatment, the amisulpride group showed greater improvement in the Letter-Number Span scores than the CBT group. Additionally, although brain metabolism in the left middle frontal gyrus, left occipital lingual gyrus, and right inferior parietal lobe was increased in all patients with schizophrenia, the amisulpride group exhibited a greater increase in metabolism in both the right superior frontal gyrus and right frontal precentral gyrus than the CBT group. Conclusion: This study suggests that a small dose of amisulpride improves the general psychopathology, working memory performance, and brain glucose metabolism of patients with schizophrenia treated with aripiprazole.
목차
등록된 정보가 없습니다.
참고문헌 (61)
참고문헌 신청
Conn PJ / 2008 / Schizophrenia : moving beyond monoamine antagonists / Mol Interv 8:99~107
Green MF / 1996 / What are the functional consequences of neurocognitive deficits in schizophrenia / Am J Psychiatry 153:321~330
McGurk SR / 2000 / The role of cognition in vocational functioning in schizophrenia / Schizophr Res 45:175~184
Lesh TA / 2011 / Cognitive control deficits in schizophrenia : mechanisms and meaning / Neuropsychopharmacology 36:316~338
Elvevåg B / 2000 / Cognitive impairment in schizophrenia is the core of the disorder / Crit Rev Neurobiol 14:1~21
Green MF / 1996 / What are the functional consequences of neurocognitive deficits in schizophrenia / Am J Psychiatry 153:321~330
McGurk SR / 2000 / The role of cognition in vocational functioning in schizophrenia / Schizophr Res 45:175~184
Lesh TA / 2011 / Cognitive control deficits in schizophrenia : mechanisms and meaning / Neuropsychopharmacology 36:316~338
Elvevåg B / 2000 / Cognitive impairment in schizophrenia is the core of the disorder / Crit Rev Neurobiol 14:1~21
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