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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 20 - 26 (7page)
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Background and Purpose This study assessed the long-term outcomes of disease-modifying therapies (DMTs) in Korean multiple sclerosis (MS) patients treated in real-world clinical settings in Korea. Methods We retrospectively evaluated the medical records of 160 patients with an initial diagnosis of clinically isolated syndrome or relapsing-remitting MS who were treated for at least 2 years. A status of 3 for no evidence of disease activity (NEDA3) was defined as no relapse, disability progression, or active lesions in annual magnetic resonance imaging (MRI) evaluations. Results Patients who were initially treated with interferon β (n=152), glatiramer acetate (n=6), or teriflunomide (n=2) were included. The mean disease duration was 8.2 years. Compared to pretreatment, annualized relapse rates were significantly reduced after treatment [from 1.0±0.8 to 0.2±0.4 (mean±standard deviation), p<0.001]. At the follow-up, 79 patients (49%) had changed their treatment regimen due to lack of efficacy (33%), side effects (14%), or other reasons (2%). Disability progression was observed in 18% of the patients over a mean treatment duration of 5.7 years. After 2 years, NEDA3 was observed in 38% of the patients. Loss of NEDA3 at 2 years was associated with long-term disability progression [odds ratio (OR)=17.975, p=0.003]. Poor response to first-line treatment was independently associated with a delay in treatment from disease onset (OR=1.238, p=0.049) and 10 or more brain lesions in the initial MRI (OR=3.648, p=0.047). Conclusions This study has provided real-world evidence that DMTs are effective in reducing disease activity and disability progression in Korean MS patients.
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참고문헌 (24)
참고문헌 신청
Kappos L / 2015 / Factors influencing long-term outcomes in relapsing-remitting multiple sclerosis : PRISMS-15 / J Neurol Neurosurg Psychiatry 86:1202~1207
University of California / 2016 / Long-term evolution of multiple sclerosis disability in the treatment era / Ann Neurol 80:499~510
Jokubaitis VG / 2016 / Predictors of long-term disability accrual in relapse-onset multiple sclerosis / Ann Neurol 80:89~100
Tintore M / 2015 / Defining high, medium and low impact prognostic factors for developing multiple sclerosis / Brain 138:1863~1874
Trojano M / 2009 / Real-life impact of early interferon beta therapy in relapsing multiple sclerosis / Ann Neurol 66:513~520
University of California / 2016 / Long-term evolution of multiple sclerosis disability in the treatment era / Ann Neurol 80:499~510
Jokubaitis VG / 2016 / Predictors of long-term disability accrual in relapse-onset multiple sclerosis / Ann Neurol 80:89~100
Tintore M / 2015 / Defining high, medium and low impact prognostic factors for developing multiple sclerosis / Brain 138:1863~1874
Trojano M / 2009 / Real-life impact of early interferon beta therapy in relapsing multiple sclerosis / Ann Neurol 66:513~520
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