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논문 기본 정보

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학술저널
저자정보
Seong Ho Hwang (Departments of Surgery Korea Cancer Center Hospital Korea Institute of Radiological and Medical Sci) Hyang Suk Choi (Departments of Surgery Korea Cancer Center Hospital Korea Institute of Radiological and Medical Sci) Yun Gyoung Kim (Departments of Surgery Korea Cancer Center Hospital Korea Institute of Radiological and Medical Sci) Ji-Hyun Kim (Departments of Surgery Korea Cancer Center Hospital Korea Institute of Radiological and Medical Sci) Min-Ki Seong (Departments of Surgery Korea Cancer Center Hospital Korea Institute of Radiological and Medical Sci) Won Il Jang (Departments of Radiation Oncology Korea Cancer Center Hospital Korea Institute of Radiological and) Sang Min Youn (Departments of Neurosurgery Korea Cancer Center Hospital Korea Institute of Radiological and Medica) Hyun-Ah Kim (Departments of Surgery Korea Cancer Center Hospital Korea Institute of Radiological and Medical Sci) Woo Chul Noh (Departments of Surgery Korea Cancer Center Hospital Korea Institute of Radiological and Medical Sci)
저널정보
한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제4권 제2호
발행연도
2016.12
수록면
85 - 91 (7page)
DOI
https://doi.org/10.14449/jbd.2016.4.2.85

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Purpose: The molecular subtype of breast cancer is an important predictive factor. Therefore, we investigated the effects of concurrent or serial radiotherapy and systemic therapy on metastatic brain lesions according to the molecular subtype of breast cancer. Methods: The present retrospective study examined data from 66 patients with breast cancer and metastatic brain lesions, who were treated using radiotherapy between January 1990 and July 2014. Patients were classified into the following three subtypes based on their hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) status: HR+/HER2? (luminal A, 13 patients), HR+/HER2+ (luminal B, 21 patients), HR?/HER2+ (HER2, 22 patients), or HR?/HER2? (triple negative, 10 patients). The brain lesions and their responses to treatment were evaluated using brain computed tomography or magnetic resonance imaging. Progression of brain disease was defined by a ≥20% increase in the sum of the lesion’s diameters or the development of a new brain lesion. Progression-free survival was calculated from the initiation of radiotherapy to the first instance of brain disease progression or last follow-up. Results: Patients in the HER2 group who had received concurrent radiotherapy and systemic therapy (mainly HER2-targeted therapy) exhibited significantly better progression-free survival than did patients who had received radiotherapy followed by systemic therapy (p=0.037). However, concurrent radiotherapy and systemic therapy did not significantly improve progression-free survival in the luminal A (p=0.527), luminal B (p=0.462), or triple negative (p=0.558) groups. Conclusion: Concurrent radiotherapy and mainly HER2-targeted systemic therapy significantly prolonged progression-free survival in the HER2 group.
#Breast neoplasms #Immunohistochemistry #Radiotherapy

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참고문헌 (20)

참고문헌 신청
Fisher B / 2002 / Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer / N Engl J Med 347:1233~1241 google schola Overgaard M / 1999 / Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial / Lancet 353:1641~1648 google schola Darby S / 2011 / Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials / Lancet 378:1707~1716 google schola Kyndi M / 2008 / Estrogen receptor, progesterone receptor, HER-2, and response to postmastectomy radiotherapy in high-risk breast cancer: the Danish Breast Cancer Cooperative Group / J Clin Oncol 26:1419~1426 google schola 김현아 / 2013 / Association of Human Epidermal Growth Factor Receptor 2 with Radiotherapy Resistance in Patients with T1N0M0 Breast Cancer / Journal of Breast Cancer 16(3):266~273 google schola

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