지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 173 - 181 (9page)
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초록· 키워드
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Objectives: The aim of this study is to develop an intelligent diagnostic system utilizing machine learning for data cleansing, then build an intelligent model and obtain new cutoff values for APRI (aspartate aminotransferase-to-platelet ratio) and FIB- 4 (fibrosis score) for the prediction and staging of fibrosis in children with chronic hepatitis C (CHC). Methods: Random forest (RF) was utilized in this study for data cleansing; then, prediction and staging of fibrosis, APRI and FIB-4 scores and their areas under the ROC curve (AUC) have been obtained on the cleaned dataset. A cohort of 166 Egyptian children with CHC was studied. Results: RF, APRI, and FIB-4 achieved high AUCs; where APRI had AUCs of 0.78, 0.816, and 0.77; FIB- 4 had AUCs of 0.74, 0.828, and 0.78; and RF had AUCs of 0.903, 0.894, and 0.822, for the prediction of any type of fibrosis, advanced fibrosis, and differentiating between mild and advanced fibrosis, respectively. Conclusions: Machine learning is a valuable addition to non-invasive methods of liver fibrosis prediction and staging in pediatrics. Furthermore, the obtained cutoff values for APRI and FIB-4 showed good performance and are consistent with some previously obtained cutoff values. There was some agreement between the predictions of RF, APRI and FIB-4 for the prediction and staging of fibrosis.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
World Health Organization / 2017 / Global hepatitis report 2017
Pokorska-Spiewak M / 2015 / Is liver biopsy still needed in children with chronic viral hepatitis / World J Gastroenterol 21(42):12141~12149
Temple JL / 2016 / A guide to non-alcoholic fatty liver disease in childhood and adolescence / Int J Mol Sci 17(6):E947
Mansoor S / 2015 / A comprehensive review of noninvasive liver fibrosis tests in pediatric nonalcoholic fatty liver disease / Curr Gastroenterol Rep 17(6):23
Valva P / 2016 / Chronic hepatitis C virus infection : serum biomarkers in predicting liver damage / World J Gastroenterol 22(4):1367~1381
Pokorska-Spiewak M / 2015 / Is liver biopsy still needed in children with chronic viral hepatitis / World J Gastroenterol 21(42):12141~12149
Temple JL / 2016 / A guide to non-alcoholic fatty liver disease in childhood and adolescence / Int J Mol Sci 17(6):E947
Mansoor S / 2015 / A comprehensive review of noninvasive liver fibrosis tests in pediatric nonalcoholic fatty liver disease / Curr Gastroenterol Rep 17(6):23
Valva P / 2016 / Chronic hepatitis C virus infection : serum biomarkers in predicting liver damage / World J Gastroenterol 22(4):1367~1381
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