Diagnostic Efficacy of Serum Mac-2 Binding Protein Glycosylation Isomer and Other Markers for Liver Fibrosis in Non-Alcoholic Fatty Liver Diseases

Jang Se Young; Tak Won Young; Park Soo Young; Kweon Young-Oh; Lee Yu Rim; Kim Gyeonghwa; Hur Keun; Han Man-Hoon; Lee Won Kee

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자료유형: 학술저널

저자정보: Jang Se Young (Department of Internal Medicine School of Medicine Kyungpook National University Kyungpook National) Tak Won Young (Department of Internal Medicine School of Medicine Kyungpook National University Kyungpook National) Park Soo Young (Department of Internal Medicine School of Medicine Kyungpook National University Kyungpook National) Kweon Young-Oh (Department of Internal Medicine School of Medicine Kyungpook National University Kyungpook National) Lee Yu Rim (Department of Internal Medicine School of Medicine Kyungpook National University Kyungpook National) Kim Gyeonghwa (Department of Biochemistry and Cell Biology Cell and Matrix Research Institute School of Medicine K) Hur Keun (Department of Biochemistry and Cell Biology Cell and Matrix Research Institute School of Medicine K) Han Man-Hoon (Department of Pathology School of Medicine Kyungpook National University Kyungpook National Univers) Lee Won Kee (Department of Medical Informatics School of Medicine Kyungpook National University Daegu Korea)

저널정보: 대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제41권 제3호

발행연도: 2021.1

수록면: 302 - 309 (8page)

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Background: Mac-2 binding protein glycosylation isomer (M2BPGi) has been established as a non-invasive biomarker for liver fibrosis. We evaluated the diagnostic efficacy of M2BPGi compared with those of other liver fibrosis markers in liver fibrosis in non-alcoholic fatty liver disease (NAFLD). Methods: We analyzed serum M2BPGi levels in 113 NAFLD patients. A pathologist graded liver fibrosis histopathologically. The diagnostic efficacies of serum M2BPGi and other liver fibrosis markers (aspartate aminotransferase to platelet ratio index, fibrosis index based on four factors, and NAFLD fibrosis score [NFS]) were evaluated using correlation, area under the ROC curve (AUC), logistic regression, and C-statistics. Results: Serum M2BPGi level and other liver fibrosis markers showed a moderate correlation with fibrosis grade. The AUC values of M2BPGi were 0.761, 0.819, 0.866, and 0.900 for diagnosing fibrosis (F)>0, F>1, F>2, and F>3, respectively. Logistic regression analysis showed M2BPGi as the only independent factor associated with F>2 and F>3. Although C-statistics showed that NFS was the best diagnostic factor for F>2 and F>3, M2BPGi with NFS had an increased C-statistics value, indicating that it is a better diagnostic model. Conclusions: The serum M2BPGi level increased with liver fibrosis severity and could be a good biomarker for diagnosing advanced fibrosis and cirrhosis in NAFLD patients. A well-controlled, prospective study with a larger sample size is needed to validate the diagnostic power of M2BPGi and other fibrosis markers in NAFLD.

#Mac-2 binding protein glycosylation isomer #Non-alcoholic fatty liver disease #Liver fibrosis #Diagnosis #Biomarker

참고문헌 (29)

참고문헌 신청

Mak LY / 2019 / Serum Mac-2-binding protein glycosylation isomer and risk of hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients / J Gastroenterol Hepatol 34:1817~1823

Shinkai N / 2018 / High levels of serum Mac-2-binding protein glycosylation isomer (M2BPGi) predict the development of hepatocellular carcinoma in hepatitis B patients treated with nucleot(s)ide analogues / J Gastroenterol 53:883~889

Nagata H / 2016 / Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy / Hepatol Int 10:956~964

Kawanaka M / 2018 / Wisteria floribunda agglutinin-positive Mac-2 binding protein predicts the development of hepatocellular carcinoma in patients with non-alcoholic fatty liver disease / Hepatol Res 48:521~528

Nishikawa H / 2016 / Clinical significance of serum Wisteria floribunda agglutinin positive Mac-2-binding protein level and high-sensitivity C-reactive protein concentration in autoimmune hepatitis / Hepatol Res 46:613~621

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