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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 42 - 51 (10page)
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Background/Aims: An estimated 80 million people worldwide are infected with viremic hepatitis C virus (HCV). Even after eradication of HCV with direct acting antivirals (DAAs), hepatic fibrosis remains a risk factor for hepatocarcinogenesis. Recently, we confirmed the applicability of microfibrillar-associated protein 4 (MFAP4) as a serum biomarker for the assessment of hepatic fibrosis. The aim of the present study was to assess the usefulness of MFAP4 as a biomarker of liver fibrosis after HCV eliminating therapy with DAAs. Methods: MFAP4 was measured using an immunoassay in 50 hepatitis C patients at baseline (BL), the end-of-therapy (EoT), and the 12-week follow-up (FU) visit. Changes in MFAP4 from BL to FU and their association with laboratory parameters including alanine aminotransferase (ALT), aspartate aminotransferase (AST), platelets, the AST to platelet ratio index (APRI), fibrosis-4 score (FIB-4), and albumin were analyzed. Results: MFAP4 serum levels were representative of the severity of hepatic fibrosis at BL and correlated well with laboratory parameters, especially APRI (Spearman correlation, R²=0.80). Laboratory parameters decreased significantly from BL to EoT. MFAP4 serum levels were found to decrease from BL and EoT to FU with high statistical significance (Wilcoxon P<0.001 for both). Conclusions: Our findings indicate that viral eradication resulted in reduced MFAP4 serum levels, presumably representing a decrease in hepatic fibrogenesis or fibrosis. Hence, MFAP4 may be a useful tool for risk assessment in hepatitis C patients with advanced fibrosis after eradication of the virus.
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참고문헌 (45)
참고문헌 신청
Gower E / 2014 / Global epidemiology and genotype distribution of the hepatitis C virus infection / J Hepatol 61(1 Suppl):S45~S57
Lerat H / 2002 / Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus / Gastroenterology 122:352~365
Perlemuter G / 2002 / Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion : a model of viral-related steatosis / FASEB J 16:185~194
Moriya K / 1997 / Hepatitis C virus core protein induces hepatic steatosis in transgenic mice / J Gen Virol 78(Pt 7):1527~1531
Gong G / 2001 / Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B / Proc Natl Acad Sci U S A 98:9599~9604
Lerat H / 2002 / Steatosis and liver cancer in transgenic mice expressing the structural and nonstructural proteins of hepatitis C virus / Gastroenterology 122:352~365
Perlemuter G / 2002 / Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion : a model of viral-related steatosis / FASEB J 16:185~194
Moriya K / 1997 / Hepatitis C virus core protein induces hepatic steatosis in transgenic mice / J Gen Virol 78(Pt 7):1527~1531
Gong G / 2001 / Human hepatitis C virus NS5A protein alters intracellular calcium levels, induces oxidative stress, and activates STAT-3 and NF-kappa B / Proc Natl Acad Sci U S A 98:9599~9604
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