개인구독
소속 기관이 없으신 경우, 개인 정기구독을 하시면 저렴하게
논문을 무제한 열람 이용할 수 있어요.
지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제3호
- 발행연도
- 2019.1
- 수록면
- 489 - 499 (11page)
이용수
초록· 키워드
오류제보하기
Subunit vaccines are safer and more stable than live vaccines although they have the disadvantage of eliciting poor immune response. To develop a subunit vaccine, an effective delivery system targeting the key elements of the protective immune response is a prerequisite. In this study, oxidized carbon nanospheres (OCNs) were used as a subunit vaccine delivery system and tuberculosis (TB) was chosen as a model disease. TB is among the deadliest infectious diseases worldwide and an effective vaccine is urgently needed. The ability of OCNs to deliver recombinant Mycobacterium tuberculosis (Mtb) proteins, Ag85B and HspX, into bone marrow derived macrophages (BMDMs) and dendritic cells (BMDCs) was investigated. For immunization, OCNs were mixed with the two TB antigens as well as the adjuvant monophosphoryl lipid A (MPL). The protective efficacy was analyzed in vaccinated mice by aerosol Mtb challenge with a virulent strain of Mtb and the bacterial burdens were measured. The results showed that OCNs are highly effective in delivering Mtb proteins into the cytosol of BMDMs and BMDCs. Upon immunization, this vaccine formula induced robust Th1 immune response characterized by cytokine profiles from restimulated splenocytes and specific antibody titer. More importantly, enhanced cytotoxic CD8+ T cell activation was observed. However, it did not reduce the bacteria burden in the lung and spleen from the aerosol Mtb challenge. Taken together, OCNs are highly effective in delivering subunit protein vaccine and induce robust Th1 and CD8+ T cell response. This vaccine delivery system is suitable for application in settings where cell-mediated immune response is needed.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Moreno-Mendieta SA / 2010 / Adjuvants in tuberculosis vaccine development / FEMS Immmunol. Med. Microbiol 58:75~84
Andersen P / 2005 / The success and failure of BCG-implications for a novel tuberculosis vaccine / Nat. Rev. Microbiol 3:656~662
Nunes-Alves C / 2014 / In search of a new paradigm for protective immunity to TB / Nat. Rev. Microbiol 12:289~299
Ottenhoff TH / 2012 / Vaccines against tuberculosis: where are we and where do we need to go? / PLoS Path 8:e1002607
Fehres CM / 2014 / Understanding the biology of antigen cross-presentation for the design of vaccines against cancer / Front. Immunol 5:149
Andersen P / 2005 / The success and failure of BCG-implications for a novel tuberculosis vaccine / Nat. Rev. Microbiol 3:656~662
Nunes-Alves C / 2014 / In search of a new paradigm for protective immunity to TB / Nat. Rev. Microbiol 12:289~299
Ottenhoff TH / 2012 / Vaccines against tuberculosis: where are we and where do we need to go? / PLoS Path 8:e1002607
Fehres CM / 2014 / Understanding the biology of antigen cross-presentation for the design of vaccines against cancer / Front. Immunol 5:149
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Potentiation of Th1-Type Immune Responses to Mycobacterium tuberculosis Antigens in Mice by Cationic Liposomes Combined with De-O-Acylated Lipooligosaccharide
Journal of Microbiology and Biotechnology
2018 .01
-
A Study on the Evaluation of Test Vaccine against Commercial Vaccine Using Hepatitis A Vaccine Efficacy Evaluation Test
한국미생물학회 학술대회논문집
2022 .10
-
Vaccine Development Program for Developing Countries, International Vaccine Institute
한국미생물학회 학술대회논문집
2016 .04
-
COVID-19 Vaccine Acceptance in the US and UK in the Early Phase of the Pandemic: AI-Generated Vaccines Hesitancy for Minors, and the Role of Governments
Journal of The Korean Data Analysis Society
2021 .01
-
Development of mRNA Vaccines/Therapeutics and Their Delivery System
Molecules and Cells
2023 .01
-
The Characteristics of RNA Vaccine
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .09
-
Apoptotic Effect of Macrophages against Mycobacterium tuberculosis
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2016 .12
-
Latest Comprehensive Knowledge of the Crosstalk between TLR Signaling and Mycobacteria and the Antigens Driving the Process
Journal of Microbiology and Biotechnology
2019 .01
-
In silico Design of Multi-epitope Vaccines Targeting Iron-regulated lipoproteins of Staphylococcus aureus Using Immunoinformactics
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2022 .12
-
Progress and Challenges in the Development of COVID-19 Vaccines and Current Understanding of SARS-CoV-2- Specific Immune Responses
Journal of Microbiology and Biotechnology
2020 .01
-
CD1b in immature dendritic cells acquires increased phagocytotic function
미생물학회지
2018 .09
-
Generation of a High-Growth Influenza Vaccine Strain in MDCK Cells for Vaccine Preparedness
Journal of Microbiology and Biotechnology
2018 .01
-
Development and Evaluation of Irradiated Bacterial Vaccine
한국미생물학회 학술대회논문집
2016 .04
-
Development of Antigen Expression System for the Establish of Vaccine Efficacy Evaluation Method against Emerging Infectious Diseases
한국미생물학회 학술대회논문집
2022 .10
-
차세대 감염병 백신
생명과학회지
2023 .09
-
Host Immune Pathways to Mycobacterium tuberculosis Infection
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2024 .09
-
In silico SARS-CoV-2 vaccine development for Omicron strain using reverse vaccinology
Genes & Genomics
2022 .08
-
Cutaneous Adverse Reaction After COVID-19 Vaccination
대한의진균학회지
2022 .09
-
Long-term Immunogenicity of a Recombinant Subunit Severe Fever with Thrombocytopenia Syndrome Virus Vaccine
한국미생물학회 학술대회논문집
2021 .08
-
Immunomodulatory Roles of PE/PPE Proteins and Their Implications in Genomic Features of Mycobacterium tuberculosis
JOURNAL OF BACTERIOLOGY AND VIROLOGY
2015 .09
이 논문의 저자 정보
최근 본 자료
댓글(0)
0