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Next-generation Vaccines for Infectious Viral Diseases
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차세대 감염병 백신

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Type
Academic journal
Author
Sun-Woo Yoon (국립안동대학교)
Journal
Korean Society Of Life Science Journal of Life Science Vol.33 No.9 KCI Accredited Journals
Published
2023.9
Pages
746 - 753 (8page)

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Next-generation Vaccines for Infectious Viral Diseases
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Viral infectious diseases have been regarded as one of the greatest threats to global public health. The recent coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a stark reminder of the threat posed by emerging viral infections. Developing and producing appropriate and efficient vaccines and therapeutics are the only options to combat this pandemic. The COVID-19 pandemic has highlighted the need for novel vaccine platforms to control and prevent emerging viral diseases. Conventional vaccine platforms, including live-attenuated vaccine and inactivated vaccines, pose limitations in the speed of vaccine development, manufacturing capacity, and broad protection for emergency use. Interestingly, vaccination with the SARS-CoV-2 vaccine candidate based on the mRNA-lipid nanoparticle (LNP) platform protected against COVID-19, confirming that the nucleoside-modified candidate is a safe and effective alternative to conventional vaccines. Moreover, the prophylactic strategies against the COVID-19 pandemic have been mRNA nucleic acid-based vaccines and nanoparticle-based platforms, which are effective against SARS-CoV-2 and its variants. Overall, the novel vaccine platform has presented advantages compared with the traditional vaccine platform in the COVID-19 pandemic. This review explores the recent advancements in vaccine technologies and platforms, focusing on mRNA vaccines, digital vaccines, and nanoparticles while considering their advantages and possible drawbacks.
#Digital vaccine #infectious disease viruses #messenger RNA #nanoparticle vaccine nextgeneration vaccine

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Ai, L., Li, Y., Zhou, L., Yao, W., Zhang, H., Hu, Z., Han, J., Wang, W., Wu, J., Xu, P., Wang, R., Li, Z., Li, Z., Wei, C., Liang, J., Chen, H., Yang, Z., Guo, M., Huang, Z., Wang, X., Zhang, Z., Xiang, W., Sun, D., Xu, L., Huang, M., Lv, B., Peng, P., Zh google schola Allen, T. M. and Cullis, P. R. 2004. Drug delivery systems: entering the mainstream. Science 303, 1818-1822. google schola Anderluzzi, G., Lou, G., Gallorini, S., Brazzoli, M., Johnson, R., O'Hagan, D. T., Baudner, B. C. and Perrie, Y. 2020. Investigating the impact of delivery system design on the efficacy of self-amplifying RNA vaccines. Vaccines (Basel) 8, 212. google schola Anderson, B. R., Muramatsu, H., Nallagatla, S. R., Bevilacqua, P. C., Sansing, L. H., Weissman, D. and Karikó, K. 2010. Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation. Nucleic Acids Res. 38, 5884-5892. google schola Arevalo, C. P., Bolton, M. J., Sage, V. L., Ye, N., Furey, C., Muramatsu, H., Alameh, M. -G., Pardi, N., Drapeau, E. M., Parkhouse, K., Garretson, T., Morris, J. S., Moncla, L. H., Tam, Y. K., Fan, S. H. Y., Lakdawala, S. S., Drew, W. and Hensley, S. E. 2 google schola

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