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논문 기본 정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제28권 제1호
- 발행연도
- 2018.1
- 수록면
- 136 - 144 (9page)
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초록· 키워드
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Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis. Bacillus Calmette-Guérin (BCG) vaccine is the only TB vaccine currently available, but it is not sufficiently effective in preventing active pulmonary TB or adult infection. With the purpose of developing an improved vaccine against TB that can overcome the limitations of the current BCG vaccine, we investigated whether adjuvant formulations containing de-O-acylated lipooligosaccharide (dLOS) are capable of enhancing the immunogenicity and protective efficacy of TB subunit vaccines. The results revealed that the dLOS/dimethyl dioctadecyl ammonium bromide (DDA) adjuvant formulation significantly increased both humoral and Th1-type cellular responses to TB subunit vaccine that are composed of three antigens, Ag85A, ESAT-6, and HspX. The adjuvanted TB vaccine also effectively induced the Th1-type response in a BCG-primed mouse model, suggesting a potential as a booster vaccine. Finally, the dLOS/ DDA-adjuvanted TB vaccine showed protective efficacy against M. tuberculosis infection in vitro and in vivo. These data indicate that the dLOS/DDA adjuvant enhances the Th1-type immunity and protective efficacy of the TB subunit vaccine, suggesting that it would be a promising adjuvant candidate for the development of a booster vaccine.
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참고문헌 (36)
참고문헌 신청
World Health Organization / 2014 / Global tuberculosis report
Kaufmann SH / 2010 / Future vaccination strategies against tuberculosis: thinking outside the box / Immunity 33:567~577
Kaufmann SH / 2012 / Tuberculosis vaccine development: strength lies in tenacity / Trends Immunol 33:373~379
Sacksteder KA / 2002 / New tuberculosis vaccine development / Expert Opin. Biol. Ther. 2:741~749
Kaufmann SHE / 2010 / New vaccines for tuberculosis / Lancet 375:2110~2119
Kaufmann SH / 2010 / Future vaccination strategies against tuberculosis: thinking outside the box / Immunity 33:567~577
Kaufmann SH / 2012 / Tuberculosis vaccine development: strength lies in tenacity / Trends Immunol 33:373~379
Sacksteder KA / 2002 / New tuberculosis vaccine development / Expert Opin. Biol. Ther. 2:741~749
Kaufmann SHE / 2010 / New vaccines for tuberculosis / Lancet 375:2110~2119
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