지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제2호
- 발행연도
- 2019.1
- 수록면
- 200 - 210 (11page)
이용수
초록· 키워드
오류제보하기
Objective: This study aimed to investigate whether maternal negative affectivity (MNA) moderates the effect of genetic polymorphism of SLC6A4 on behavior problems in children. Methods: Study participants comprised 143 preschoolers and their mothers from South Korea. The Childhood Behavior Checklist and Emotionality, Activity, and Sociability adult scale were used to measure child behavior and maternal affectivity. DNA from saliva was genotyped to determine serotonin transporter polymorphism. Results: MNA appeared to exert effects in externalizing (b =5.78, p＜0.001) and internalizing problems (b =6.09, p＜ 0.001). Interaction between SLCA4 polymorphism and MNA showed effects on externalizing (b =−7.62, p＜0.01) and internalizing problems (b =−9.77, p＜0.01). Children with two short alleles showed considerable differences in both externalizing and internalizing problems according to MNA; however, children with one short allele or none showed relatively few differences in behavior problems due to maternal affectivity. Conclusion: The effect of SLC6A4 polymorphism on child behavior seemed to be moderated by MNA. In addition, the impact of MNA was found to vary based on a child’s genetic risk. High MNA may trigger the risk allele while low MNA causes the risk allele to illicit less behavior problems. Children with two short variants of the SLC6A4 gene may benefit from intervention that modulates MNA.
목차
등록된 정보가 없습니다.
참고문헌 (79)
참고문헌 신청
Bauermeister JJ / 2006 / Development of adaptable and flexible treatment manuals for externalizing and internalizing disorders in children and adolescents / Rev Bras Psiquiatr 28:67~71
Grillo E / 2004 / Early manifestations of behavioral disorders in children and adolescents / J Pediatr (Rio J) 80(2 Suppl):S21~S27
Achenbach TM / 1979 / The child behavior profile: II. boys aged 12-16 and girls aged 6-11 and 12-16 / J Consult Clin Psychol 47:223~233
Angold A / 1999 / Comorbidity / J Child Psychol Psychiatry 40:57~87
Russo MF / 1994 / Comorbidity of childhood anxiety and externalizing disorders : prevalence, associated characteristics, and validation issues / Clin Psychol Rev 14:199~221
Grillo E / 2004 / Early manifestations of behavioral disorders in children and adolescents / J Pediatr (Rio J) 80(2 Suppl):S21~S27
Achenbach TM / 1979 / The child behavior profile: II. boys aged 12-16 and girls aged 6-11 and 12-16 / J Consult Clin Psychol 47:223~233
Angold A / 1999 / Comorbidity / J Child Psychol Psychiatry 40:57~87
Russo MF / 1994 / Comorbidity of childhood anxiety and externalizing disorders : prevalence, associated characteristics, and validation issues / Clin Psychol Rev 14:199~221
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Vulnerable Strata to Non-Adherence and Overuse in Treatment for Patients with Cognitive Impairment
Dementia and Neurocognitive Disorders(대한치매학회지)
2020 .01
-
독거노인과 가족동거노인의 가구형태가 혈압, 체질량지수, 간이영양평가점수 및 생화학적 지표에 미치는 영향
가정간호학회지
2019 .01
-
Effect of Polymorphisms of Three Genes Mediating Monoamine Signalling on Brain Morphometry in Schizophrenia and Healthy Subjects
Clinical Psychopharmacology and Neuroscience
2015 .01
-
Association of rs10757274 and rs2383206 Polymorphisms on 9p21 locus with Coronary Artery Disease in Turkish Population
Korean Circulation Journal
2016 .01
-
Transcriptional regulation of genetic variants in the SLC40A1 promoter
The Korean Journal of Physiology & Pharmacology
2024 .03
-
Association Study between Norepinephrine Transporter Gene Polymorphism and Schizophrenia in a Korean Population
PSYCHIATRY INVESTIGATION
2015 .01
-
농촌지역 주민의 영양결핍 및 사회심리적 요인과 근감소증 가능군과의 관련성
농촌의학·지역보건
2022 .06
-
The SLC29A3 Variant, Neutrophilic Dermatosis, and Hyperferritinemia Imitate Systemic Juvenile Idiopathic Arthritis in a Saudi Child: A Case Report
대한류마티스학회지
2023 .04
-
Roles of CYP2C9 and its variants (CYP2C9*2 and CYP2C9*3) in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone
Journal of Pharmaceutical Investigation
2020 .01
-
북한의 ‘아동권리협약 국가이행보고서’에 나타난 모자보건사업과 국내외 모자보건사업 분석
Health & Nursing
2023 .05
-
mRNA Expression of SLC5A5 and SLC2A Family Genes in Papillary Thyroid Cancer: An Analysis of The Cancer Genome Atlas
Yonsei Medical Journal
2018 .01
-
The Association between the Apolipoprotein E Gene Polymorphism and All-cause Mortality in the Korean Population
Journal of Korean Medical Science
2019 .01
-
The cis-AB01 Allele Originated From the A105 Allele, and not From the A102 Allele
Annals of Laboratory Medicine
2015 .01
-
The Impact of Maternal Adverse Childhood Experiences on Offspring’s Internalizing and Externalizing Problems
PSYCHIATRY INVESTIGATION
2021 .11
-
미숙아로 출생한 유아의 행동문제 관련요인
Child Health Nursing Research
2016 .01
-
Detection of MYCN Amplification in Serum DNA Using Conventional Polymerase Chain Reaction
Journal of Korean Medical Science
2016 .01
-
청소년의 외재화 및 내재화 문제행동에 영향을 미치는 요인 : 고등학교 1학년 학생을 중심으로
한국간호교육학회지
2016 .05
-
노인의 영양상태에 영향을 미치는 구강건강 요인
한국치위생학회지
2018 .01
-
Aberrant Hypomethylation of Solute Carrier Family 6 Member 12 Promoter Induces Metastasis of Ovarian Cancer
Yonsei Medical Journal
2017 .01
-
The Impact of Maternal Personality Traits on Child Behavioral Problems in Preschool Ages : A Population Based Panel Study in Korea
대한소아청소년정신의학회 학술대회논문집
2019 .11
이 논문의 저자 정보
최근 본 자료
댓글(0)
0