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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제2호
- 발행연도
- 2019.1
- 수록면
- 311 - 320 (10page)
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초록· 키워드
오류제보하기
Fusobacterium nucleatum is a morbific agent in periodontitis and halitosis. Egg yolk antibody (IgY) was obtained from egg yolks from chickens stimulated with F. nucleatum. This study was to assess the effectiveness of IgY on periodontitis and halitosis caused by F. nucleatum in vitro and in vivo. The growth of F. nucleatum was inhibited (p <0. 05) by different concentrations of IgY in vitro and the results of a Halimeter show volatile sulfur compounds (VSCs) were reduced to 904 ± 57 ppb at a concentration 40 mg/ml of IgY. The changes of fatty acids of F. nucleatum were determined using GC-MS. The scores for odor index of rat saliva were decreased. The major constituent of volatile organic compounds (VOCs) including short-chain acids decreased 46.2% in 10 mg/ml IgY, ammonia decreased 70% in 40 mg/ml IgY, while aldehydes and olefine ketones were almost unchanged. The ELISA assay revealed that IL-6 and TNF-α were decreased after 4 weeks’ IgY treatment. Morphometric (X-ray) and histological analyses (HE) showed that IgY reduced alveolar bone loss and collagen fibers became orderly in rat models. As a result, IgY may have the potential to treat periodontitis and halitosis.
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참고문헌 (39)
참고문헌 신청
Amou T / 2014 / Relationship between halitosis and periodontal disease-associated oral bacteria / Int. J. Dent. Hyg 12:145~151
Goldberg S / 1994 / Cadaverine as a putative component of oral malodor / J. Dent. Res 73:1168~1172
Phillips M / 1999 / Variation in volatile organic compounds in the breath of normal humans / J. Chromatogr. B. Biomed. Sci. Appl 729:75~88
Oh TJ / 2002 / Periodontal diseases in the child and adolescent / J. Clin. Periodontol 29:400~410
Kolenbrander PE / 2002 / Communication among oral bacteria / Microbiol. Mol. Biol. Rev 66:486~505
Goldberg S / 1994 / Cadaverine as a putative component of oral malodor / J. Dent. Res 73:1168~1172
Phillips M / 1999 / Variation in volatile organic compounds in the breath of normal humans / J. Chromatogr. B. Biomed. Sci. Appl 729:75~88
Oh TJ / 2002 / Periodontal diseases in the child and adolescent / J. Clin. Periodontol 29:400~410
Kolenbrander PE / 2002 / Communication among oral bacteria / Microbiol. Mol. Biol. Rev 66:486~505
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