지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 39 - 53 (15page)
이용수
초록· 키워드
오류제보하기
Colorectal cancer (CRC) is recognized as the third most common malignancy worldwide. Previous studies indicated several genetic and environmental factors that potentiate CRC. However, the role of microbiota in the etiology of CRC is becoming a major concern nowadays. Fusobacterium nucleatum (F. nucleatum), an anaerobic bacterium, mostly resides in the oral cavity and is a causative agent of various oral inflammatory diseases. It is evident from the recent studies that F. nucleatum is present in abundance in the CRC tissues as compared to the adjacent normal tissues. F. nucleatum has certain virulence factors like FadA and Fap2 which help in its adhesion to the mucosal cells and promotes carcinogenesis. Besides that, these virulence factors induce cytokine production and recruitment of inflammatory cells, hence it creates an environment favorable for neoplastic growth. Furthermore, F. nucleatum can suppress the host immune system by interfering with normal functions of macrophages, dendritic cells, T cells, tumor-associated neutrophils and natural killer cells. It was also revealed that CRC patients with high numbers of F. nucleatum showed drug resistance and cancer recurrence. From the previous investigations, it was concluded that F. nucleatum has a diagnostic as well as prognostic value for CRC patients. In the present study, we have outlined the current data on the detection methods, pathogenic mechanisms, immunosuppression effects and clinical management of F. nucleatum-associated CRC.
목차
INTRODUCTION
DETECTION METHODS OF F. NUCLEATUM IN CRC
POTENTIAL ROLE OF F. NUCLEATUM IN CRC
F. NUCLEATUM PROMOTES EPIGENETIC CHANGES IN CRC
F. NUCLEATUM AND HOST IMMUNITY
ROLE OF F. NUCLEATUM IN DRUG RESISTANCE
SCREENING AND PREVENTION STRATEGIES OF F. NUCLEATUM-ASSOCIATED CRC
CLINICAL MANAGEMENT OF F. NUCLEATUM-ASSOCIATED CRC
CONCLUSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
담배 연기 응축물이 Fusobacterium nucleatum subsp. nucleatum에 미치는 영향
미생물학회지
2022 .03
-
The methyltransferase CmoM from Fusobacterium nucleatum: purification, crystallization, and X-ray crystallographic analysis
Biodesign
2024 .09
-
Screening Microbes for the Antagonistic Effect against Fusobacterium nucleatum
한국미생물학회 학술대회논문집
2021 .08
-
Complete genome sequence of Fusobacterium nucleatum KCOM 1323 isolated from a human subgingival plaque of periodontitis lesion
미생물학회지
2017 .09
-
Establishment of a Gastric Culture Collection and Screening Microbes for Antagonistic Activity against Fusobacterium nucleatum
한국미생물학회 학술대회논문집
2020 .10
-
Effect of IgY on Periodontitis and Halitosis Induced by Fusobacterium nucleatum
Journal of Microbiology and Biotechnology
2019 .01
-
Gut Microbiome and colorectal cancer: discovery of bacterial changes with metagenomics application in Turkısh population
Genes & Genomics
2024 .09
-
Comprehensive RNA-sequencing analysis of colorectal cancer in a Korean cohort
Molecules and Cells
2024 .01
-
Does Turmeric/curcumin Supplementation Change Anthropometric Indices in Patients with Non-alcoholic Fatty Liver Disease? A Systematic Review and Meta-analysis of Randomized Controlled Trials
Clinical Nutrition Research
2019 .01
-
Long non-coding RNA H19X promotes tumorigenesis and metastasis of colorectal cancer through regulating the miR-503-5p/KANK1 axis
Genes & Genomics
2022 .12
-
Integration of single-cell transcriptomics and epigenetic analysis reveals enhancer-controlled TIMP1 as a regulator of ferroptosis in colorectal cancer
Genes & Genomics
2024 .01
-
SOX11-dependent CATSPER1 expression controls colon cancer cell growth through regulation the PI3K/AKT signaling pathway
Genes & Genomics
2022 .11
-
LINC00174 Facilitates Proliferation and Migration of Colorectal Cancer Cells via MiR-3127-5p/ E2F7 Axis
Journal of Microbiology and Biotechnology
2021 .08
-
Coenzyme A transferase Fn1856-Fn1857 from Fusobacterium nucleatum: purification, crystallization, and X-ray crystallographic analysis
Biodesign
2024 .06
-
MicroRNA 429 regulates MMPs expression by modulating TIMP2 expression in colon cancer cells and inflammatory colitis
Genes & Genomics
2024 .07
-
MicroRNA-31 과발현을 이용한 대장암의 예후예측 및 전이예측 바이오마커 발굴
생명과학회지
2016 .06
-
Epigenetic Silencing of CHOP Expression by the Histone Methyltransferase EHMT1 Regulates Apoptosis in Colorectal Cancer Cells
Molecules and Cells
2022 .09
-
LncRNA H19/miR-29b-3p/PGRN Axis Promoted Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Acting on Wnt Signaling
Molecules and Cells
2018 .03
-
Transcription Factor E2F7 Hampers the Killing Effect of NK Cells against Colorectal Cancer Cells via Activating RAD18 Transcription
Journal of Microbiology and Biotechnology
2024 .04
이 논문의 저자 정보
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2021-475-001852329