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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 379 - 385 (7page)
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Objective To evaluate the association of GRIK2 and NLGN1 with autism spectrum disorder in a Chinese population. Methods We performed spatio-temporal expression analysis of GRIK2 and NLGN1 in the developing prefrontal cortex, and examined the expression of the genes in ASD cases and healthy controls using the GSE38322 data set. Following, we performed a case-control study in a Chinese population. Results The analysis using the publicly available expression data showed that GRIK2 and NLGN1 may have a role in the development of human brain and contribute to the risk of ASD. Later genetic analysis in the Chinese population showed that the GRIK2 rs6922753 for the T allele, TC genotype and dominant model played a significant protective role in ASD susceptibility (respectively: OR=0.840, p=0.023; OR=0.802, p=0.038; OR=0.791, p=0.020). The NLGN1 rs9855544 for the G allele and GG genotype played a significant protective role in ASD susceptibility (respectively: OR=0.844, p=0.019; OR=0.717, p=0.022). After adjusting p values, the statistical significance was lost (p>0.05). Conclusion Our results suggested that GRIK2 rs6922753 and NLGN1 rs9855544 might not confer susceptibility to ASD in the Chinese population.
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등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Bemben MA / 2014 / CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses / Nat Neurosci 17:56~64
Meldrum BS / 2000 / Glutamate as a neurotransmitter in the brain: review of physiology and pathology / J Nutr 130(4S Suppl):1007S~1015S
Sampaio AS / 2011 / Association between polymorphisms in GRIK2 gene and obsessivecompulsive disorder : a family-based study / CNS Neurosci Ther 17:141~147
Xing J / 2016 / Resequencing and association analysis of six PSD-95-related genes as possible susceptibility genes for schizophrenia and autism spectrum disorders / Sci Rep 6:27491
Lanore F / 2012 / Deficits in morphofunctional maturation of hippocampal mossy fiber synapses in a mouse model of intellectual disability / J Neurosci 32:17882~17893
Meldrum BS / 2000 / Glutamate as a neurotransmitter in the brain: review of physiology and pathology / J Nutr 130(4S Suppl):1007S~1015S
Sampaio AS / 2011 / Association between polymorphisms in GRIK2 gene and obsessivecompulsive disorder : a family-based study / CNS Neurosci Ther 17:141~147
Xing J / 2016 / Resequencing and association analysis of six PSD-95-related genes as possible susceptibility genes for schizophrenia and autism spectrum disorders / Sci Rep 6:27491
Lanore F / 2012 / Deficits in morphofunctional maturation of hippocampal mossy fiber synapses in a mouse model of intellectual disability / J Neurosci 32:17882~17893
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