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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제2호
- 발행연도
- 2019.1
- 수록면
- 121 - 130 (10page)
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Glutamate toxicity-mediated mitochondrial dysfunction and neuronal cell death are involved in the pathogenesis of several neurodegenerative diseases as well as acute brain ischemia/stroke. In this study, we investigated the neuroprotective mechanism of dieckol (DEK), one of the phlorotannins isolated from the marine brown alga Ecklonia cava, against glutamate toxicity. Primary cortical neurons (100 M, 24 h) and HT22 neurons (5 mM, 12 h) were stimulated with glutamate to induce glutamate toxic condition. The results demonstrated that DEK treatment significantly increased cell viability in a dose-dependent manner (1–50 M) and recovered morphological deterioration in glutamate-stimulated neurons. In addition, DEK strongly attenuated intracellular reactive oxygen species (ROS) levels, mitochondrial overload of Ca2+ and ROS, mitochondrial membrane potential (Δm) disruption, adenine triphosphate depletion. DEK showed free radical scavenging activity in the cell-free system. Furthermore, DEK enhanced protein expression of heme oxygenase-1 (HO- 1), an important anti-oxidant enzyme, via the nuclear translocation of nuclear factorlike 2 (Nrf2). Taken together, we conclude that DEK exerts neuroprotective activities against glutamate toxicity through its direct free radical scavenging property and the Nrf-2/HO-1 pathway activation.
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참고문헌 (38)
참고문헌 신청
Choi DW / 1988 / Glutamate neurotoxicity and diseases of the nervous system / Neuron 1:623~634
Orrenius S / 2003 / Regulation of cell death : the calcium-apoptosis link / Nat Rev Mol Cell Biol 4:552~565
Duchen MR / 2012 / Mitochondria, calcium-dependent neuronal death and neurodegenerative disease / Pflugers Arch 464:111~121
Ha JS / 2010 / Nox4-dependent H2O2 production contributes to chronic glutamate toxicity in primary cortical neurons / Exp Cell Res 316:1651~1661
Peng TI / 2010 / Oxidative stress caused by mitochondrial calcium overload / Ann N Y Acad Sci 1201:183~188
Orrenius S / 2003 / Regulation of cell death : the calcium-apoptosis link / Nat Rev Mol Cell Biol 4:552~565
Duchen MR / 2012 / Mitochondria, calcium-dependent neuronal death and neurodegenerative disease / Pflugers Arch 464:111~121
Ha JS / 2010 / Nox4-dependent H2O2 production contributes to chronic glutamate toxicity in primary cortical neurons / Exp Cell Res 316:1651~1661
Peng TI / 2010 / Oxidative stress caused by mitochondrial calcium overload / Ann N Y Acad Sci 1201:183~188
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