지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 411 - 413 (3page)
이용수
초록· 키워드
오류제보하기
Dear Editor, Levels of phytosterols, including plant sterols and stanols, are increased in lipid storage disorders such as cerebrotendinous xanthomatosis (CTX) and sitosterolemia. Both are autosomal recessive diseases with heterogeneous clinical manifestations, such as tendon xanthoma, cataracts, and progressive neurologic abnormalities. Decreased bile acid synthesis in CTX leads to the accumulation of cholestanol [1], whereas increased intestinal absorption and decreased biliary excretion in sitosterolemia lead to increased sitosterol and campesterol levels [2]. If appropriately treated, the outcomes of both diseases can dramatically improve. However, it is difficult to measure phytosterol levels using standard diagnostic assays. For example, enzymatic colorimetry, based on the reaction with a C-5 double bond or the presence of a 3β-hydroxyl group, cannot differentiate between cholesterol and phytosterols because these groups are present in both sterol types [3, 4]. Among the methods that can properly measure phytosterol levels, mass spectrometry (MS) is deemed superior because of its high analytical sensitivity and specificity. We developed and evaluated a triplex phytosterol assay utilizing gas chromatography (GC-MS). The study was approved by the Institutional Review Board of Seoul National University Hospital and Seoul National University Bundang Hospital (E-1901-001-998).
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Kuriyama M / 1991 / High levels of plant sterols and cholesterol precursors in cerebrotendinous xanthomatosis / J Lipid Res 32:223~229
Eun-Gyong Yoo / 2016 / Sitosterolemia: a review and update of pathophysiology, clinical spectrum, diagnosis, and management / Annals of Pediatirc Endocrinology & Metabolism 21(1):7~14
Kidambi S / 2008 / Sitosterolaemia : pathophysiology, clinical presentation and laboratory diagnosis / J Clin Pathol 61:588~594
Escola-Gil JC / 2014 / Sitosterolemia : diagnosis, investigation, and management / Curr Atheroscler Rep 16:424
CSLI / 2003 / Evaluation of the linearity of quantitative measurement procedures: a statistical approach; approved guideline. CLSI document EP06-A / Clinical and Laboratory Standards Institute
Eun-Gyong Yoo / 2016 / Sitosterolemia: a review and update of pathophysiology, clinical spectrum, diagnosis, and management / Annals of Pediatirc Endocrinology & Metabolism 21(1):7~14
Kidambi S / 2008 / Sitosterolaemia : pathophysiology, clinical presentation and laboratory diagnosis / J Clin Pathol 61:588~594
Escola-Gil JC / 2014 / Sitosterolemia : diagnosis, investigation, and management / Curr Atheroscler Rep 16:424
CSLI / 2003 / Evaluation of the linearity of quantitative measurement procedures: a statistical approach; approved guideline. CLSI document EP06-A / Clinical and Laboratory Standards Institute
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Sitosterolemia: a review and update of pathophysiology, clinical spectrum, diagnosis, and management
Annals of Pediatirc Endocrinology & Metabolism
2016 .01
-
Phytosterol ginsenoside F2 attenuates non-alcoholic fatty liver disease through selective activation of liver X receptor
한국실험동물학회 학술발표대회 논문집
2019 .07
-
High-performance liquid chromatography analysis of phytosterols in Panax ginseng root grown under different conditions
Journal of Ginseng Research
2018 .01
-
Sonographic Findings of Polyneuropathy Associated With Cerebrotendinous Xanthomatosis: A Case Report
Annals of Rehabilitation Medicine
2017 .01
-
CTx might Take Over RT
대한외과학회 학술대회 초록집
2018 .11
-
Quality and characteristics of fermented ginseng seed oil based on bacterial strain and extraction method
Journal of Ginseng Research
2017 .07
-
강활(Ostericum koreanum) 줄기의 성분
생약학회지(Korean Journal of Pharmacognosy)
2020 .09
-
Back to the Basics of Liquid Chromatography-Mass Spectrometry
Annals of Laboratory Medicine
2022 .03
-
Occurrence of CTX-M-producing Escherichia coli from in broilers with colibacillosis
예방수의학회지
2022 .09
-
The Ameliorative Effect of β-sitosterol on DNCB-induced Atopic Dermatitis in Mice
대한의생명과학회지
2017 .12
-
임상검사실에서의 액체크로마토그래피-질량분석법에 대한 제언: 도입과 운영
Laboratory Medicine Online
2020 .01
-
A Sensitive Determination of Plasma Free Fatty Acids Following Tert-butyldimethylsilyl Derivatization using Gas Chromatography-Mass Spectrometry for Screening of Fatty Acid Oxidation Disorders
대한유전성대사질환학회지
2017 .01
-
CTX-M 광범위 베타락탐 분해효소의 그룹별 내성표현형 차이
Annals of Clinical Microbiology
2019 .01
-
Lipid
대한외과학회 학술대회 초록집
2016 .11
-
Ascorbate Oxidase Minimizes Interference by High-Concentration Ascorbic Acid in Total Cholesterol Assays
Annals of Laboratory Medicine
2016 .01
-
We Did It: A to Z at University Hospital
대한외과학회 학술대회 초록집
2019 .10
-
Decision on Chemotherapy Amidst COVID-19 Pandemic: a Review and a Practical Approach from Iran
Infection and Chemotherapy
2020 .01
-
Role of Adjuvant Thoracic Radiation Therapy and Full Dose Chemotherapy in pN2 Non-small Cell Lung Cancer: Elucidation Based on Single Institute Experience
Cancer Research and Treatment
2017 .01
-
Racial disparity in Predictive Value of 21-Gene Recurrence Score Assay: A Population-Based Study Using the SEER Database
대한외과학회 학술대회 초록집
2021 .05
-
Screening newborns for metabolic disorders based on targeted metabolomics using tandem mass spectrometry
Annals of Pediatirc Endocrinology & Metabolism
2015 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0