지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 880 - 889 (10page)
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초록· 키워드
오류제보하기
Purpose The optimal adjuvant therapy modality for treating pN2 non-small cell lung cancer patients has not yet been established. In this study, the authors investigated clinical outcomes following three different adjuvant therapy modalities.
Materials and Methods From January 2006 to December 2012, 240 patients with cN0/1 disease were found to have pN2 disease following curative resection and received one of three adjuvant therapy modalities: thoracic radiation therapy (TRT) and concurrent chemotherapy (CTx) (CCRT) (group I), CCRT plus consolidation CTx (group II), and CTx alone (group III). TRT was delivered to 155 patients (groups I/II), and full dose CTx was delivered to 172 patients either as a consolidative or a sole modality (group II/III).
Results During 30 months of median follow-up, 44 patients died and 141 developed recurrence.
The 5-year overall survival (OS), locoregional control (LRC), distant metastasis-free survival (DMFS), and disease-free survival (DFS) rates of all patients were 76.2%, 80.7%, 36.4%, and 29.6%, respectively. There was no difference in OS among groups. TRT (groups I/II) significantly improved LRC, full dose CTx (groups II/III) did DMFS, and CCRT plus consolidation CTx (group II) did DFS, respectively.
Conclusion The current study could support that TRT could improve LRC and full dose CTx could improve DMFS and that CCRT plus consolidation CTx could improve DFS.
목차
등록된 정보가 없습니다.
참고문헌 (18)
참고문헌 신청
Billiet C / 2014 / Modern post-operative radiotherapy for stage III non-small cell lung cancer may improve local control and survival : a meta-analysis / Radiother Oncol 110
Bradley JD / 2005 / Phase II trial of postoperative adjuvant paclitaxel/carboplatin and thoracic radiotherapy in resected stage II and IIIA non-small-cell lung cancer : promi
Dai H / 2011 / Postoperative radiotherapy for resected pathological stage IIIA-N2 nonsmall cell lung cancer : a retrospective study of 221 cases from a single institution /
Douillard JY / 2006 / Adjuvant vinorelbine plus cisplatin versus observation in patients with com
Douillard JY / 2008 / Impact of postoperative radiation therapy on survival in patients with complete resection and stage I, II, or IIIA non-small-cell lung cancer treated w
Bradley JD / 2005 / Phase II trial of postoperative adjuvant paclitaxel/carboplatin and thoracic radiotherapy in resected stage II and IIIA non-small-cell lung cancer : promi
Dai H / 2011 / Postoperative radiotherapy for resected pathological stage IIIA-N2 nonsmall cell lung cancer : a retrospective study of 221 cases from a single institution /
Douillard JY / 2006 / Adjuvant vinorelbine plus cisplatin versus observation in patients with com
Douillard JY / 2008 / Impact of postoperative radiation therapy on survival in patients with complete resection and stage I, II, or IIIA non-small-cell lung cancer treated w
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