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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 371 - 378 (8page)
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Epitranscriptome refers to any relevant changes in gene expression without changes in RNA sequences. Similar to epigenetic changes, the epitranscriptomic changes are in general mediated by post-transcriptional chemical modifications of RNA species. Recently, mRNA modifications, especially both N6-methyladenosine (m6A) and N1-methyladenosine (m1A), have received significant attention as proteins responsible for generating, removing or recognizing m6A modification have been identified. m6A in eukaryotic cells including human and mouse was initially identified in early 1970s. However, the function of the modification has not been intensively studied because of technical limitations. Recently, using next-generation sequencing (NGS) technology, several groups revealed transcriptome-wide distribution of m6A and its both in vitro and in vivo roles in biological processes such as metabolism and development. The review focuses on recent progress in mRNA modification and stem cell biology. In addition, an integrated landscape of m6A enrichments in both human and mouse embryonic stem cells (ESCs) is presented using publically available datasets.
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참고문헌 (84)
참고문헌 신청
Aas PA / 2003 / Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA / Nature 421:859~863
Adams JM / 1975 / Modified nucleosides and bizarre 50-termini in mouse myeloma mRNA / Nature 255:28~33
Agarwala SD / 2012 / RNA methylation by the MIS complex regulates a cell fate decision in yeast / PLoS Genet 8:e1002732
Aguilo F / 2015 / Coordination of m(6)A mRNA methylation and gene transcription by ZFP217 regulates pluripotency and reprogramming / Cell Stem Cell 17:689~704
Alexandrov A / 2002 / Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA / RNA 8:1253~1266
Adams JM / 1975 / Modified nucleosides and bizarre 50-termini in mouse myeloma mRNA / Nature 255:28~33
Agarwala SD / 2012 / RNA methylation by the MIS complex regulates a cell fate decision in yeast / PLoS Genet 8:e1002732
Aguilo F / 2015 / Coordination of m(6)A mRNA methylation and gene transcription by ZFP217 regulates pluripotency and reprogramming / Cell Stem Cell 17:689~704
Alexandrov A / 2002 / Two proteins that form a complex are required for 7-methylguanosine modification of yeast tRNA / RNA 8:1253~1266
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