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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 214 - 217 (4page)
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초록· 키워드
오류제보하기
Various commercial assays have recently been developed for detecting glutamate dehydrogenase (GDH) and/or toxin A/B to diagnose Clostridioides difficile infection (CDI). We compared the performance of two assays for the simultaneous detection of C. difficile GDH and toxin A/B, using 150 stool samples: C. DIFF QUIK CHEK COMPLETE (QCC; TechLab, Blacksburg, VA, USA) and RIDASCREEN Clostridium difficile GDH (RC-GDH) and Toxin A/B (RC-Toxin A/B; R-Biopharm, Darmstadt, Germany). For GDH detection, QCC and RC-GDH showed satisfactory sensitivity (95.7% and 94.3%, respectively) and specificity (92.5% and 93.8%, respectively) compared with C. difficile culture. For toxin A/B detection, QCC showed higher sensitivity than RC-Toxin A/B (60.0% vs 33.3%, P<0.001) compared with toxigenic C. difficile culture. When the results of QCC or RC-GDH+RC-Toxin A/B were used as the first step of a two-step algorithm for diagnosing CDI, QCC permitted more accurate discrimination than RC of positive or negative results for CDI (77.3% and 65.3%, respectively). QCC is useful for the simultaneous detection of C. difficile GDH and toxin A/B as a part of the two-step algorithm for diagnosing CDI.
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등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Makristathis A / 2017 / Comprehensive evaluation of chemiluminescent immunoassays for the laboratory diagnosis of Clostridium difficile infection / Eur J Clin Microbiol Infect Dis 36:1253~1259
신보문 / 2016 / Evaluation of Xpert C. difficile, BD MAX Cdiff, IMDx C. difficile for Abbott m2000, and Illumigene C. difficile Assays for Direct Detection of Toxigenic Clostridium difficile in Stool Specimens / Annals of Laboratory Medicine 36(2):131~137
Nobuaki Mori / 2018 / Characteristics and Immunological Roles of Surface Layer Proteins in Clostridium difficile / Annals of Laboratory Medicine 38(3):189~195
Planche T / 2011 / Reference assays for Clostridium difficile infection : one or two gold standards / J Clin Pathol 64:1~5
Debast SB / 2014 / European Society of Clinical Microbiology and Infectious Diseases. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection / Clin Microbiol Infect 20:1~26
신보문 / 2016 / Evaluation of Xpert C. difficile, BD MAX Cdiff, IMDx C. difficile for Abbott m2000, and Illumigene C. difficile Assays for Direct Detection of Toxigenic Clostridium difficile in Stool Specimens / Annals of Laboratory Medicine 36(2):131~137
Nobuaki Mori / 2018 / Characteristics and Immunological Roles of Surface Layer Proteins in Clostridium difficile / Annals of Laboratory Medicine 38(3):189~195
Planche T / 2011 / Reference assays for Clostridium difficile infection : one or two gold standards / J Clin Pathol 64:1~5
Debast SB / 2014 / European Society of Clinical Microbiology and Infectious Diseases. European Society of Clinical Microbiology and Infectious Diseases: update of the treatment guidance document for Clostridium difficile infection / Clin Microbiol Infect 20:1~26
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