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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제4호
- 발행연도
- 2019.1
- 수록면
- 571 - 576 (6page)
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초록· 키워드
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Microenvironmental stress, which is naturally observed in solid tumors, has been implicated in anticancer drug resistance. This tumor-specific stress causes the degradation of topoisomerase IIα, rendering cells resistant to topoisomerase IIα-targeted anticancer agents. In addition, microenvironmental stress can induce the overexpression of 78kDa glucose regulated protein (GRP78), which can subsequently block the activation of apoptosis induced by treatment with anticancer agents. Therefore, inhibition of topoisomerase IIα degradation and reduction in GRP78 expression may be effective strategies for inhibiting anticancer drug resistance. In this study, we investigated the active compound arctigenin, which inhibited microenvironmental stress-induced etoposide resistance in HT-29 cells. Arctigenin was also highly toxic to etoposide-resistant HT-29 cells, with an IC50 value of 10 μM for colony formation. We further showed that arctigenin inhibited the degradation of topoisomerase IIα and reduced the expression of GRP78. Thus, these results suggest that arctigenin is a novel therapeutic agent that inhibits resistance to etoposide associated with microenvironmental stress conditions.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Goodman GE / 1987 / Effect of verapamil on in vitro cytotoxicity of adriamycin and vinblastine in human tumor cells / Cancer Res 47:2295~2304
안희정 / 2008 / 천연 추출물을 이용한 화학감작제 후보물질 탐색 / 생명과학회지 18(9):1244~1248
Shen D W / 2000 / Decreased accumulation of [14C] carboplatin in human cisplatin-resistant cells results from reduced energy dependent uptake / J. Cell Physiol 183:108~116
Goto S / 2002 / Significance of nuclear glutathione S-transferase pi in resistance to anti-cancer drugs / Jpn. J. Cancer Res 93:1047~1056
Axelson H / 2005 / Hypoxia-induced dedifferentiation of tumor cells–A mechanism behind heterogeneity and aggressiveness of solid tumors / Semin. Cell DevBiol 16:554~563
안희정 / 2008 / 천연 추출물을 이용한 화학감작제 후보물질 탐색 / 생명과학회지 18(9):1244~1248
Shen D W / 2000 / Decreased accumulation of [14C] carboplatin in human cisplatin-resistant cells results from reduced energy dependent uptake / J. Cell Physiol 183:108~116
Goto S / 2002 / Significance of nuclear glutathione S-transferase pi in resistance to anti-cancer drugs / Jpn. J. Cancer Res 93:1047~1056
Axelson H / 2005 / Hypoxia-induced dedifferentiation of tumor cells–A mechanism behind heterogeneity and aggressiveness of solid tumors / Semin. Cell DevBiol 16:554~563
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