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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제25권 제5호
- 발행연도
- 2015.1
- 수록면
- 648 - 657 (10page)
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H9, a novel herbal extract, demonstrated cytotoxicity in A549 non-small cell lung cancer (NSCLC) cell lines. In this study, we investigated whether H9, and/or co-treatment with an anticancer drug, pemetrexed (PEM), inhibited tumor growth in BALB/c nude mice models bearing A549 NSCLC cells. The mice were separated into groups and administered H9 and PEM for 2 weeks. Protein and mRNA levels were detected using western blotting and reverse transcription polymerase chain reaction, respectively; immunohistochemistry (IHC) was also performed on the tumor tissues. H9 and co-treatment with PEM induced the cleavage of proapoptotic factors, such as caspase-3, caspase-8, caspase-9, and poly(ADP)-ribose polymerase (PARP). Expression levels of cell-death receptors involving Fas/FasL, TNF-related apoptosisinducing ligands (TRAIL), and TRAIL receptors were increased by H9 and co-treatment with PEM. Furthermore, analysis of levels of cell-cycle modulating proteins indicated that tumor cells were arrested in the G1/S phase. In addition, the phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/Akt survival signaling pathways were inhibited by H9 and co-treatment with PEM. In conclusion, H9 and co-treatment with PEM inhibited tumor growth in BALB/c nude mice models bearing A549 NSCLC cells. These results indicate that H9 and co-treatment with PEM can be used as an anticancer therapy in NSCLC.
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참고문헌 (26)
참고문헌 신청
Ashkenazi A / 1998 / Death receptors: signaling and modulation / Science 281 : 1305 ~ 1308
Azrak RG / 2004 / Therapeutic synergy between irinotecan and 5-fluorouracil against human tumor xenografts / Clin. Cancer Res 10 : 1121 ~ 1129
Ban JO / 2009 / Thiacremonone augments chemotherapeutic agentinduced growth inhibition in human colon cancer cells through inactivation of nuclear factor-{kappa}B / Mol. Canc
Brunet A / 1999 / Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor / Cell 96 : 857 ~ 868
Butt MS / 2009 / Green tea: nature's defense against malignancies / Crit. Rev. Food Sci. Nutr 49 : 463 ~ 473
Azrak RG / 2004 / Therapeutic synergy between irinotecan and 5-fluorouracil against human tumor xenografts / Clin. Cancer Res 10 : 1121 ~ 1129
Ban JO / 2009 / Thiacremonone augments chemotherapeutic agentinduced growth inhibition in human colon cancer cells through inactivation of nuclear factor-{kappa}B / Mol. Canc
Brunet A / 1999 / Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor / Cell 96 : 857 ~ 868
Butt MS / 2009 / Green tea: nature's defense against malignancies / Crit. Rev. Food Sci. Nutr 49 : 463 ~ 473
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