지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 214 - 220 (7page)
이용수
초록· 키워드
오류제보하기
Cancer has emerged as one of the leading cause of deaths worldwide. A three-dimensional quantitative structure-activity relationship (3D-QSAR) analysis was performed on a series of quinazoline-based anticancer agents. Purpose of the study is to understand the structural basis for their inhibitory activity. Comparative molecular field analysis (CoMFA) technique was employed to develop 3D-QSAR model. Ligand-based alignment scheme was used to generate a reliable CoMFA model. The model produced statistically significant results with a cross-validated correlation coefficient ($q^2$) of 0.589 and a non-cross-validated correlation coefficient ($r^2$) of 0.928. Model was further validated by bootstrapping and progressive scrambling analysis. This study could assist in the design of novel and more potent anticancer agents.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
A CoMFA Study of Glycogen Synthase Kinase 3 Inhibitors
조선자연과학논문집
2015 .01
-
3D-QSAR Studies of 8-Substituted-2-aryl-5-alkylaminoquinolines as Corticotropin-releasing Factor-1 Receptor Antagonists
조선자연과학논문집
2015 .01
-
Topomer CoMFA Analysis of Xanthine Oxidase inhibitors
조선자연과학논문집
2017 .01
-
3D QSAR Studies of Mps1 (TTK) Kinase Inhibitors Based on CoMFA
조선자연과학논문집
2016 .01
-
3D QSAR Study of 2-Methoxyphenylpiperazinylakanamides as 5-Hydroxytryptamine (Serotonin) Receptor 7 Antagonists
조선자연과학논문집
2016 .01
-
Pharmacokinetics of SH003 which is a candidate for new anticancer agent in rat
한국분석과학회 학술대회
2016 .11
-
3D-QSAR Study on Imidazopyridazines Derivatives as Potent Pim-1 Kinase Inhibitors using Region-Focused CoMFA
조선자연과학논문집
2017 .01
-
Identification of a novel boosting agent for the anticancer response of conventional topoisomerase inhibitors
한국분석과학회 학술대회
2022 .05
-
Fabrication of a 3D cell chip for evaluation of anticancer drug on cancer cell
한국진공학회 학술발표회초록집
2016 .08
-
Fragment based QSAR Analysis of CXCR-2 Inhibitors Using Topomer CoMFA Approach
조선자연과학논문집
2017 .01
-
3D-QSAR Studies on 2-(indol-5-yl)thiazole Derivatives as Xanthine Oxidase (XO) Inhibitors
조선자연과학논문집
2015 .01
-
Anticancer effect of Holmium coated magnetic nanoparticles on prostate cancer in vivo model
한국진공학회 학술발표회초록집
2016 .08
-
A PCR Denaturing Gradient Gel Electrophoresis (DGGE) Analysis of Intestinal Microbiota in Gastric Cancer Patients Taking Anticancer Agents
생명과학회지
2017 .11
-
Complete Genome Sequence of Antibiotic and Anticancer Agent Violacein Producing Massilia sp. Strain NR 4-1
한국미생물학회 학술대회논문집
2016 .04
-
Total internal reflection fluorescence detection system-based determination of the anticancer activity of camptothecin against breast cancer stem cells
한국분석과학회 학술대회
2017 .05
-
Comparative Molecular Field Analysis of CXCR-2 Inhibitors
조선자연과학논문집
2016 .01
-
감귤 돌연변이체의 인간 암세포 증식 억제와 자연사멸 증강효과
생명과학회지
2015 .09
-
Comparative Molecular Field Analysis of Pyrrolopyrimidines as LRRK2 Kinase Inhibitors
조선자연과학논문집
2016 .01
-
Drug Redirecting an Anticancer to an Antibacterial Based on the Naphthoquinone Pharmacophore
한국미생물학회 학술대회논문집
2019 .04
-
Anticancer Effect of Thymol on AGS Human Gastric Carcinoma Cells
Journal of Microbiology and Biotechnology
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0