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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 495 - 502 (8page)
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The 5-HT6R has been considered as an attractive therapeutic target in the brain due to its exclusive expression in the brain. However, the mechanistic linkage between 5-HT6Rs and brain functions remains poorly understood. Here, we examined the effects of 5-HT6R-mediated cell morphological changes using immunocytochemistry, Western blot, and live-cell imaging assays. Our results showed that the activation of 5-HT6Rs caused morphological changes and increased cell surface area in HEK293 cells expressing 5-HT6Rs. Treatment with 5-HT specifically increased RhoA-GTP activity without affecting other Rho family proteins, such as Rac1 and Cdc42. Furthermore, live-cell imaging in hippocampal neurons revealed that activation of 5-HT6Rs using a selective agonist, ST1936, increased the density and size of dendritic protrusions along with the activation of RhoA-GTP activity and that both effects were blocked by pretreatment with a selective 5-HT6R antagonist, SB258585. Taken together, our results show that 5-HT6R plays an important role in the regulation of cell morphology via a RhoA-dependent pathway in mammalian cell lines and primary neurons.
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참고문헌 (22)
참고문헌 신청
Cho, E. / 2015 / Cyclin Y inhibits plasticity-induced AMPA receptor exocytosis and LTP / Sci. Rep 5:12624
Deraredj Nadim, W. / 2016 / Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity / Proc. Natl. Acad. Sci. USA 113:12310~12315
Duhr, F. / 2014 / Cdk5induces constitutive activation of 5-HT6 receptors to promote neurite growth / Nat. Chem. Biol 10:590~597
Filip, M. / 2009 / Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system / Pharmacol. Rep 61:761~777
Fone, K. C. F. / 2008 / An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function / Neuropharmacology 55:1015~1022
Deraredj Nadim, W. / 2016 / Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity / Proc. Natl. Acad. Sci. USA 113:12310~12315
Duhr, F. / 2014 / Cdk5induces constitutive activation of 5-HT6 receptors to promote neurite growth / Nat. Chem. Biol 10:590~597
Filip, M. / 2009 / Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system / Pharmacol. Rep 61:761~777
Fone, K. C. F. / 2008 / An update on the role of the 5-hydroxytryptamine6 receptor in cognitive function / Neuropharmacology 55:1015~1022
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