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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.9
- 수록면
- 159 - 171 (13page)
- DOI
- https://doi.org/10.1186/s40824-018-0130-1
이용수
초록· 키워드
오류제보하기
Background: Magnetic resonance imaging is one of the diagnostic tools that uses magnetic particles as contrast agents. It is noninvasive methodology which provides excellent spatial resolution. Although magnetic resonance imaging offers great temporal and spatial resolution and rapid in vivo images acquisition, it is less sensitive than other methodologies for small tissue lesions, molecular activity or cellular activities. Thus, there is a desire to develop contrast agents with higher efficiency. Contrast agents are known to shorten both T1 and T2. Gadolinium based contrast agents are examples of T1 agents and iron oxide contrast agents are examples of T2 agents. In order to develop high relaxivity agents, gadolinium or iron oxide-based contrast agents can be synthesized via conjugation with targeting ligands or functional moiety for specific interaction and achieve accumulation of contrast agents at disease sites. Main body: This review discusses the principles of magnetic resonance imaging and recent efforts focused on specificity of contrast agents on specific organs such as liver, blood, lymph nodes, atherosclerotic plaque, and tumor. Furthermore, we will discuss the combination of theranostic such as contrast agent and drug, contrast agent and thermal therapy, contrast agent and photodynamic therapy, and neutron capture therapy, which can provide for cancer diagnosis and therapeutics. Conclusion: These applications of magnetic resonance contrast agents demonstrate the usefulness of theranostic agents for diagnosis and treatment.
목차
등록된 정보가 없습니다.
참고문헌 (132)
참고문헌 신청
Pysz MA / 2010 / Molecular imaging: current status and emerging strategies / Clin Radiol 65:500~516
Sumer B / 2008 / Theranostic nanomedicine for cancer
Ugander M / 2012 / Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction / J Am Coll Cardiol Img 5:596~603
Chalela JA / 2007 / Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison / Lancet 369:293~298
Yao L / 1988 / Occult intraosseous fracture: detection with MR imaging / Radiology 167:749~751
Sumer B / 2008 / Theranostic nanomedicine for cancer
Ugander M / 2012 / Myocardial edema as detected by pre-contrast T1 and T2 CMR delineates area at risk associated with acute myocardial infarction / J Am Coll Cardiol Img 5:596~603
Chalela JA / 2007 / Magnetic resonance imaging and computed tomography in emergency assessment of patients with suspected acute stroke: a prospective comparison / Lancet 369:293~298
Yao L / 1988 / Occult intraosseous fracture: detection with MR imaging / Radiology 167:749~751
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