지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제17권 제3호
- 발행연도
- 2019.1
- 수록면
- 453 - 457 (5page)
이용수
초록· 키워드
오류제보하기
We report an extremely rare case of a patient with hypoxic-ischemic brain injury who recovered consciousness and motor and cognitive functions due to paradoxical response after zolpidem administration. A 32-year-old woman who had attempted suicide by hanging was admitted. The patient had stabilized in a state of drowsy mentality, quadriparesis, dysphagia, and impaired cognition. Brain magnetic resonance imaging was suggestive of hypoxic ischemic brain injury and unilateral infarction in the right posterior cerebral artery territory. Due to sleep disturbance, zolpidem was administered, and paradoxically consciousness level and function returned to near-normal during the duration of the drug-effect. In addition to previous reports, our case characteristically showed remarkable motor and cognitive function recovery, not only consciousness level. The drug-effect time was gradually decreased after 18 months and absent after 3 years. We have reviewed related literature and discussed possible neuropharmacological and neurobiological mechanism.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Chang Jae Kim / 2016 / Zolpidem-Induced Arousal by Paradoxical GABAergic Stimulation: A Case Report With F-18 Flumazenil Positron Emission Tomography and Single Photon Emission Computed Tomography Study / Annals of Rehabilitation Medicine 40(1):177~181
Jeong-Ok Lee / 2018 / Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder / Clinical Psychopharmacology and Neuroscience 16(4):461~468
Thonnard M / 2013 / Effect of zolpidem in chronic disorders of consciousness : a prospective open-label study / Funct Neurol 28:259~264
Clauss R / 2006 / Drug induced arousal from the permanent vegetative state / NeuroRehabilitation 21:23~28
Rowlett JK / 1996 / Assessment of benzodiazepine receptor heterogeneity in vivo: apparent pA2 and pKB analyses from behavioral studies / Psychopharmacology(Berl) 128:1~16
Jeong-Ok Lee / 2018 / Predictors of Cognitive Improvement during 12 Weeks of Antidepressant Treatment in Patients with Major Depressive Disorder / Clinical Psychopharmacology and Neuroscience 16(4):461~468
Thonnard M / 2013 / Effect of zolpidem in chronic disorders of consciousness : a prospective open-label study / Funct Neurol 28:259~264
Clauss R / 2006 / Drug induced arousal from the permanent vegetative state / NeuroRehabilitation 21:23~28
Rowlett JK / 1996 / Assessment of benzodiazepine receptor heterogeneity in vivo: apparent pA2 and pKB analyses from behavioral studies / Psychopharmacology(Berl) 128:1~16
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