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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 138 - 143 (6page)
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초록· 키워드
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Background and Purpose Lacosamide (LCM) is an antiepileptic drug that enhances the slow inactivation of sodium channels and modulates collapsin response mediator protein-2. LCM was recently demonstrated to exert a neuroprotective effect in a murine model of trau¬matic brain injury and status epilepticus. Assuming the same underlying excitotoxicity-related brain injury mechanism, we hypothesized that LCM would have a neuroprotective effect in hypoxic-ischemic brain injury.
Methods We divided rats into three groups at each testing session: pre- or postfed with LCM, fed with normal saline, and sham. A hypoxic-ischemic brain injury was induced by subjecting 7-day-old rats to right carotid artery coagulation followed by 2.5 h of exposure to 8% oxygen. The animals were killed on postnatal day 12 to evaluate the severity of brain damage. Open field testing was also performed between week 2 and week 6, and the Morris water maze test was performed in week 7 after hypoxia-ischemia.
Results The incidence of liquefactive cerebral infarction was lower in rats prefed with LCM at 100 mg/kg/dose, with the mortality rate being higher at higher doses (200 and 300 mg/kg/dose). The infarct areas were smaller in LCM-prefed rats in several brain regions including the hemisphere, hippocampus, cortex, and striatum. Spatial learning and memory function were better in LCM-prefed rats (p<0.05). No effect was observed in postfed rats.
Conclusions This study suggests that LCM pretreatment exerts a neuroprotective effect on hypoxia-ischemia in neonatal rats. The obtained results suggest that LCM pretreatment could be used as an effective neuroprotective method for neonates under hypoxic-ischemic condi¬tions including heart surgery.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Arundine M / 2003 / Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity / Cell Calcium 34 : 325 ~ 337
Beydoun A / 2009 / Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partialonset seizures / Expert Rev Neurother 9 : 33 ~ 42
Beyreuther BK / 2007 / Lacosamide: a review of preclinical properties / CNS Drug Rev 13 : 21 ~ 42
Calabresi P / 2000 / Cellular factors controlling neuronal vulnerability in the brain: a lesson from the striatum / Neurology 55 : 1249 ~ 1255
Calabresi P / 2003 / Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia / Ann Neurol 53 : 693 ~ 702
Beydoun A / 2009 / Lacosamide: pharmacology, mechanisms of action and pooled efficacy and safety data in partialonset seizures / Expert Rev Neurother 9 : 33 ~ 42
Beyreuther BK / 2007 / Lacosamide: a review of preclinical properties / CNS Drug Rev 13 : 21 ~ 42
Calabresi P / 2000 / Cellular factors controlling neuronal vulnerability in the brain: a lesson from the striatum / Neurology 55 : 1249 ~ 1255
Calabresi P / 2003 / Antiepileptic drugs as a possible neuroprotective strategy in brain ischemia / Ann Neurol 53 : 693 ~ 702
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