지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 177 - 181 (5page)
이용수
초록· 키워드
오류제보하기
Zolpidem is a non-benzodiazepine drug that has selectivity for the gamma-aminobutyric acid (GABA) receptors. We experienced paradoxical effect of zolpidem in a 48-year-old male patient with hypoxic-ischemic brain injury after cardiac arrest. The patient was in stupor and could not communicate. His Glasgow Coma Scale (GCS) was E2M4V2 and Rancho Los Amigos (RLA) was grade III to IV. Zolpidem was prescribed to induce sedation but paradoxically, he became alert (GCS 15, RLA VII) and was able to communicate. The arousal lasted for 2 hours repeatedly following each administration of the medication. While he was alert, electroencephalogram showed the reversal of slow wave into beta range fast activity and F-18 flumazenil positron emission tomography (PET) showed increased GABAergic receptor activity in both frontoparietotemporal cortices. Single photon emission computed tomography (SPECT) also showed increased cerebral perfusion and reversal of cerebellar diaschisis.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Clauss R / 2006 / Drug induced arousal from the permanent vegetative state / NeuroRehabilitation 21:23~28
Clauss RP / 2000 / Extraordinary arousal from semi-comatose state on zolpidem: a case report / S Afr Med J 90:68~72
Whyte J / 2014 / Zolpidem and restoration of consciousness / Am J Phys Med Rehabil 93:101~113
Thonnard M / 2013 / Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study / Funct Neurol 28:259~264
Brefel-Courbon C / 2007 / Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy / Ann Neurol 62:102~105
Clauss RP / 2000 / Extraordinary arousal from semi-comatose state on zolpidem: a case report / S Afr Med J 90:68~72
Whyte J / 2014 / Zolpidem and restoration of consciousness / Am J Phys Med Rehabil 93:101~113
Thonnard M / 2013 / Effect of zolpidem in chronic disorders of consciousness: a prospective open-label study / Funct Neurol 28:259~264
Brefel-Courbon C / 2007 / Clinical and imaging evidence of zolpidem effect in hypoxic encephalopathy / Ann Neurol 62:102~105
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