지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Background: The molecular pathways of how endocrine disruptors affect bone mineral density (BMD) and bone remodeling are still unclear. The purpose of this experimental study is to determine the effects of di(2-ethylhexyl)phthalate (DEHP) on bone metabolism in ovariectomized mice. Methods: Twenty-six-month-old female CD-1 mice were divided into 4 groups: control, low-dose DEHP, high-dose DEHP, and estrogen groups (n=5, each group). All mice were subjected to ovariectomy for the induction of artificial menopause and then exposed to corn oil, DEHP, and estrogen for 2 months. Micro-computed tomography (Micro-CT) of the bone and analysis of blood samples for bone markers were performed to observe the changes in bone metabolism. Results: Osteocalcin level was decreased in the control, low-dose and high-dose DEHP group, the reduction width was greater in the high-dose DEHP group (-0.219 ng/mL) than control group (-0.077 ng/mL, P<0.05). C-terminal telopeptide of type I collagen level was increased in the control, low-dose and high-dose DEHP group, the increase range of low-dose DEHP group (0.329 ng/mL) showed greater than control group (0.093 ng/mL, P<0.05). Micro-CT analysis revealed that the BMD was significantly lower in the high-dose DEHP group (19.8×10-2 g/cm3) than control group (27.2×10-2 g/cm3, P<0.05). The structure model index was significantly higher in the high-dose DEHP group (2.737) than low-dose DEHP group (2.648) and estrogen group (2.63, P<0.05). It means the progression of osteoporosis in the high-dose DEHP group. Conclusions: These results confirm the negative effects of DEHP on bone health in ovariectomized mice. Further continuous studies on genetic pathways and other endocrine disruptors will be necessary to validate these findings.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Roy JR / 2009 / Estrogen-like endocrine disrupting chemicals affecting puberty in humans--a review / Med Sci Monit 15:Ra137~Ra145
Migliaccio S / 1996 / Alterations of maternal estrogen levels during gestation affect the skeleton of female offspring / Endocrinology 137:2118~2125
Migliaccio S / 2000 / Transient estrogen exposure of female mice during early development permanently affects osteoclastogenesis in adulthood / Bone 27:47~52
Hermsen SA / 2008 / In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects bone tissue in rhesus monkeys / Toxicology 253:147~152
Sabbieti MG / 2009 / Involvement of p53 in phthalate effects on mouse and rat osteoblasts / J Cell Biochem 107:316~327
Migliaccio S / 1996 / Alterations of maternal estrogen levels during gestation affect the skeleton of female offspring / Endocrinology 137:2118~2125
Migliaccio S / 2000 / Transient estrogen exposure of female mice during early development permanently affects osteoclastogenesis in adulthood / Bone 27:47~52
Hermsen SA / 2008 / In utero and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) affects bone tissue in rhesus monkeys / Toxicology 253:147~152
Sabbieti MG / 2009 / Involvement of p53 in phthalate effects on mouse and rat osteoblasts / J Cell Biochem 107:316~327
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Distribution of urinary DEHP metabolites in obese children
환경독성보건학회 심포지엄 및 학술대회
2019 .04
-
DEHP Down-Regulates Tshr Gene Expression in Rat Thyroid Tissues and FRTL-5 Rat Thyrocytes: A Potential Mechanism of Thyroid Disruption
Endocrinology and Metabolism
2021 .01
-
Risk assessment of di(2-ethylhexyl)phthalate in the workplace
환경독성보건학회 심포지엄 및 학술대회
2016 .06
-
Effects of maternal exposure to di(2-ethylhexyl) phthalate (DEHP) on susceptibility to juvenile asthma in mouse model
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Transcriptional response of the immune related HSP67B2 gene in the intertidal crab Macrophthalmus japonicus exposed to DEHP
환경독성보건학회 심포지엄 및 학술대회
2020 .09
-
Risk assessment of di(2-ethylhexyl) phthalate in the workplace
Environmental Analysis Health and Toxicology
2016 .12
-
Temporal trends of di(2-ethylhexyl) phthalate exposure and allergic disease in the Korean general population
환경독성보건학회 심포지엄 및 학술대회
2023 .05
-
고려홍삼의 조사포닌이 Di(2-ethylexyl phthalate에 의해 유발된 호흡기독성에 미치는 영향
동의생리병리학회지
2024 .08
-
Low Dose Exposure to Di-2-Ethylhexylphthalate in Juvenile Rats Alters the Expression of Genes Related with Thyroid Hormone Regulation
Biomolecules & Therapeutics(구 응용약물학회지)
2018 .01
-
Stability study of docetaxel solution (0.9%, saline) using Non-PVC and PVC tubes for intravenous administration
생체재료학회지
2015 .03
-
토양매체에서 지렁이를 이용한 bisphenol A, DEHP, nonylphenol 급성독성 평가
환경독성보건학회 심포지엄 및 학술대회
2016 .10
-
Expressions of stress marker genes effected by DEHP exposure in non-biting midge larvae (Chironomus flaviplumus)
환경독성보건학회 심포지엄 및 학술대회
2021 .10
-
Tumor growth with di-(2-ethylhexyl) phthalate is regulated by primary cilium formation through H2O2 production-mediated thymosin β4 gene expression
한국실험동물학회 학술발표대회 논문집
2021 .07
-
The Role of Di(2-Ethylhexyl) Phthalate as an Exacerbating Factor in Chronic Spontaneous Urticaria
Allergy, Asthma & Immunology Research
2022 .05
-
Association between urinary phthalate metabolites and obesity in adult Korean population: Korean National Environmental Health Survey (KoNEHS), 2012-2014
대한직업환경의학회지
2019 .09
-
Significantly Low Effective Dose from <sup>18</sup>FDG PET/CT Scans Using Dose Reducing Strategies: "Lesser is Better"
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Prioritization and Alternative Zebrafish Embryonic Assay for Endocrine Disruption Potential of Six phthalates
환경독성보건학회 심포지엄 및 학술대회
2017 .10
-
서울시 초등학교 실내 먼지 중 프탈레이트 오염실태 조사
한국환경보건학회지
2020 .10
-
Uncertainty Assessment: Relative versus Absolute Point Dose Measurement for Patient Specific Quality Assurance in EBRT
의학물리
2017 .09
-
폐암의 호흡동조방사선치료 시 변형영상정합을 이용한 4차원 선량평가
대한방사선치료학회지
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0