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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 45 - 49 (5page)
- DOI
- 10.1186/s40824-014-0023-x
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초록· 키워드
오류제보하기
Background: Di-2-ethylhexyl phthalate (DEHP) are added to poly(vinyl chloride)(PVC) infusion tubes as a plasticizer to ensure tube flexibility. In addition to previously reported disadvantages of DEHP, released DEHP molecules from PVC tubes can easily interact with surfactants in anticancer drug solutions (i.e., polysorbate 80 for Taxotere®-Inj) and reduce the solubility of docetaxel in aqueous solution during anticancer drug administration. Results: In this study, we investigated the in vitro stability of docetaxel in a 0.9% saline solution under an intravenous administration condition using a PVC tube (high DEHP content) and non-PVC infused tube. Conclusion: The docetaxel solution circulating through the non-PVC tube had better solution stability than through the PVC tube(high DEHP content).
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등록된 정보가 없습니다.
참고문헌 (9)
참고문헌 신청
Hanawa T. / 2005 / Release behavior of diethylhexyl phthalate from the polyvinyl-chloride tubing used for intravenous administration and the plasticized PVC membrane / Internat J Pharm 297:30~37
Demore’ B. / 2002 / Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous etoposide solution / J Clinical Pharm Therap 27:139~142
Joel AT. / 2001 / Health risks posed by use of di-2-ethylhexyl phthalate(DEHP)in PVC medical devices : A critical review / Am J Ind Med 39:100~111
Koch HM. / 2006 / Di(2-ethylhexyl)phthalate(DEHP) : human metabolism and internal exposure-an update and latest results / Int J Androl 29:155~165
Anna T. / 2009 / Investigation into the sorption of nitroglycerin and diazepam into PVC tubes and alternative tube materials during application / Int J Pharm 369:30~37
Demore’ B. / 2002 / Leaching of diethylhexyl phthalate from polyvinyl chloride bags into intravenous etoposide solution / J Clinical Pharm Therap 27:139~142
Joel AT. / 2001 / Health risks posed by use of di-2-ethylhexyl phthalate(DEHP)in PVC medical devices : A critical review / Am J Ind Med 39:100~111
Koch HM. / 2006 / Di(2-ethylhexyl)phthalate(DEHP) : human metabolism and internal exposure-an update and latest results / Int J Androl 29:155~165
Anna T. / 2009 / Investigation into the sorption of nitroglycerin and diazepam into PVC tubes and alternative tube materials during application / Int J Pharm 369:30~37
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