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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 환경독성보건학회 Environmental Analysis Health and Toxicology Environmental Health and Toxicology Vol.31
- 발행연도
- 2016.12
- 수록면
- 66 - 71 (6page)
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Objectives A hazard assessment of di(2-ethylhexyl) phthalate (DEHP), a commonly used workplace chemical, was conducted in order to protect the occupational health of workers. A literature review, consisting of both domestic and international references, examined the chemical management system, working environment, level of exposure, and possible associated risks. This information may be utilized in the future to determine appropriate exposure levels in working environments.
Methods Hazard assessment was performed using chemical hazard information obtained from international agencies, such as Organization for Economic Cooperation and Development-generated Screening Information Data Set and International Program on Chemical Safety. Information was obtained from surveys conducted by the Minister of Employment and Labor (“Survey on the work environment”) and by the Ministry of Environment (“Survey on the circulation amount of chemicals”). Risk was determined according to exposure in workplaces and chemical hazard.
Results In 229 workplaces over the country, 831 tons of DEHP have been used as plasticizers, insecticides, and ink solvent. Calculated 50% lethal dose values ranged from 14.2 to 50 g/kg, as determined via acute toxicity testing in rodents. Chronic carcinogenicity tests revealed cases of lung and liver degeneration, shrinkage of the testes, and liver cancer. The no-observed-adverse-effect level and the lowest-observed-adverse-effect level were determined to be 28.9 g/kg and 146.6 g/kg, respectively. The working environment assessment revealed the maximum exposure level to be 0.990 mg/㎥, as compared to the threshold exposure level of 5 mg/㎥. The relative risk of chronic toxicity and reproductive toxicity were 0.264 and 0.330, respectively, while the risk of carcinogenicity was 1.3, which is higher than the accepted safety value of one.
Conclusions DEHP was identified as a carcinogen, and may be dangerous even at concentrations lower than the occupational exposure limit. Therefore, we suggest management of working environments, with exposure levels below 5 mg/㎥ and all workers utilizing local exhaust ventilation and respiratory protection when handling DEHP.
Methods Hazard assessment was performed using chemical hazard information obtained from international agencies, such as Organization for Economic Cooperation and Development-generated Screening Information Data Set and International Program on Chemical Safety. Information was obtained from surveys conducted by the Minister of Employment and Labor (“Survey on the work environment”) and by the Ministry of Environment (“Survey on the circulation amount of chemicals”). Risk was determined according to exposure in workplaces and chemical hazard.
Results In 229 workplaces over the country, 831 tons of DEHP have been used as plasticizers, insecticides, and ink solvent. Calculated 50% lethal dose values ranged from 14.2 to 50 g/kg, as determined via acute toxicity testing in rodents. Chronic carcinogenicity tests revealed cases of lung and liver degeneration, shrinkage of the testes, and liver cancer. The no-observed-adverse-effect level and the lowest-observed-adverse-effect level were determined to be 28.9 g/kg and 146.6 g/kg, respectively. The working environment assessment revealed the maximum exposure level to be 0.990 mg/㎥, as compared to the threshold exposure level of 5 mg/㎥. The relative risk of chronic toxicity and reproductive toxicity were 0.264 and 0.330, respectively, while the risk of carcinogenicity was 1.3, which is higher than the accepted safety value of one.
Conclusions DEHP was identified as a carcinogen, and may be dangerous even at concentrations lower than the occupational exposure limit. Therefore, we suggest management of working environments, with exposure levels below 5 mg/㎥ and all workers utilizing local exhaust ventilation and respiratory protection when handling DEHP.
목차
Introduction
Materials and Methods
Results
Discussion
References
참고문헌 (12)
참고문헌 신청
Ministry of Environment / 2011 / National chemicals management plan (2011-2020): reduce the risk of human health and the environment with chemicals management :3~5
Beon SH / 2012 / Risk assessment of toxic chemicals (I) :12~82
Ministry of Employment and Labor / 2014 / Occupational health and safety statute book / Ministry of Employment and Labor :250~262
Kim CN / 2012 / Risk assessment of toxic chemicals (II) :151~153
Krauskopf LG / 1973 / Studies on the toxicity of phthalates via ingestion / Environ Health Perspect 3:61~72
Beon SH / 2012 / Risk assessment of toxic chemicals (I) :12~82
Ministry of Employment and Labor / 2014 / Occupational health and safety statute book / Ministry of Employment and Labor :250~262
Kim CN / 2012 / Risk assessment of toxic chemicals (II) :151~153
Krauskopf LG / 1973 / Studies on the toxicity of phthalates via ingestion / Environ Health Perspect 3:61~72
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UCI(KEPA) : I410-ECN-0101-2017-539-002198399