지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
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Background and Purpose As risk of hemorrhagic stroke may have early life origins, we investigated associations of birth weight and childhood body mass index (BMI) with adult intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH). Methods We included 240,234 Danish schoolchildren, born 1936 to 1989, with information on birth weight and measured weights and heights from 7 to 13 years. We calculated hazard ratios (HRs) and confidence intervals (CIs) for the associations between early life anthropometrics and ICH or SAH, identified through linkage with national registers. Results During the study period, 1,947 individuals (39% women) experienced an ICH and 797 individuals (64% women) experienced a SAH. Per 500 g increase in birth weight, women had a 10% decreased risk of SAH (HR, 0.90; 95% CI, 0.83 to 0.97) and men had a 10% decreased risk of ICH (HR, 0.90; 95% CI, 0.85 to 0.95). Birth weight was not associated with risks of ICH in women or SAH in men. In men, a childhood BMI below average (BMI z-score <0) was associated with increased risks of ICH. The association was stronger at older childhood ages, and at 13 years a BMI z-score of –1 was associated with a HR of 1.17 (95% CI, 1.06 to 1.28), and a BMI z-score of –2 with a HR of 1.46 (95% CI, 1.17 to 1.82) for ICH. Childhood BMI was not associated with risks of ICH in women or with risks of SAH in both sexes. Conclusions Early life body size is associated with ICH and SAH, and the associations differ by sex.
목차
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참고문헌 (30)
참고문헌 신청
Krishnamurthi RV / 2013 / Global and regional burden of first-ever ischaemic and haemorrhagic stroke during 1990-2010: findings from the Global Burden of Disease Study 2010 / Lancet Glob Health 1:e259~e281
Feigin VL / 2016 / Global burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 / Lancet Neurol 15:913~924
Donnan GA / 2008 / Stroke / Lancet 371:1612~1623
Qureshi AI / 2009 / Intracerebral haemorrhage / Lancet 373:1632~1644
Meschia JF / 2014 / Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 45:3754~3832
Feigin VL / 2016 / Global burden of stroke and risk factors in 188 countries, during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 / Lancet Neurol 15:913~924
Donnan GA / 2008 / Stroke / Lancet 371:1612~1623
Qureshi AI / 2009 / Intracerebral haemorrhage / Lancet 373:1632~1644
Meschia JF / 2014 / Guidelines for the primary prevention of stroke: a statement for healthcare professionals from the American Heart Association/American Stroke Association / Stroke 45:3754~3832
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