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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 113 - 118 (6page)
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The small ubiquitin-related modification molecule (SUMO), one of the post-translational modification molecules, is involved in a variety of cellular functions where it regulates protein activity and stability, transcription, and cell cycling. Modulation of protein SUMOylation or deSUMOylation modification has been associated with regulation of carcinogenesis in breast cancer. In the dynamic processes of SUMOylation and deSUMOylation in a variety of cancers, SUMO proteases (SENPs), reverse SUMOylation by isopeptidase activity and SENPs are mostly elevated, and are related to poor patient prognosis. Although underlying mechanisms have been suggested for how SENPs participate in breast cancer tumorigenesis, such as through regulation of target protein transactivation, cancer cell survival, cell cycle, or other post-translational modification-related machinery recruitment, the effect of SENP isoform-specific inhibitors on the progression of breast cancer have not been well evaluated. This review will introduce the functions of SENP1 and SENP2 and the underlying signaling pathways in breast cancer for use in discovery of new biomarkers for diagnosis or therapeutic targets for treatment.
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참고문헌 (65)
참고문헌 신청
Sorlie T / 2001 / Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications / Proc Natl Acad Sci U S A 98:10869~10874
Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295:2492~2502
Sunam Mander / 2018 / Nafamostat mesilate negatively regulates the metastasis of triple-negative breast cancer cells / Archives of Pharmacal Research 41(2):229~242
Rakha EA / 2009 / Triple-negative breast cancer : distinguishing between basal and nonbasal subtypes / Clin Cancer Res 15:2302~2310
Pearce ST / 2004 / The biological role of estrogen receptors alpha and beta in cancer / Crit Rev Oncol Hematol 50:3~22
Carey LA / 2006 / Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study / JAMA 295:2492~2502
Sunam Mander / 2018 / Nafamostat mesilate negatively regulates the metastasis of triple-negative breast cancer cells / Archives of Pharmacal Research 41(2):229~242
Rakha EA / 2009 / Triple-negative breast cancer : distinguishing between basal and nonbasal subtypes / Clin Cancer Res 15:2302~2310
Pearce ST / 2004 / The biological role of estrogen receptors alpha and beta in cancer / Crit Rev Oncol Hematol 50:3~22
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