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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 48 - 54 (7page)
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Purpose: To analyze and compare the clinical factors and neurodevelopmental out�comes compare early- and late-onset periventricular leukomalacia (PVL) in very low birth weight infants (VLBWI). Methods: We performed a retrospective study involving 199 newborn infants weigh�ing <1,500 g admitted to the neonatal intensive care unit between March 2009 and December 2015. VLBWI with PVL were categorized into early- and late-onset PVL groups based on the time of diagnosis based on 28 days of age. We analyzed the cli�nical factors and neurodevelopmental outcomes between the groups. Results: The incidence rate of PVL was 10.1% (16/158). The Apgar score at 1 minute and the mean duration of tocolytic therapy were associated with the development of PVL. The incidence rate of premature rupture of membranes (PROM) was significantly higher in the early-onset PVL group (P=0.041). No significant differences were observ�ed in neurodevelopmental outcomes between the early- and late-onset PVL groups. Conclusion: Results suggest that a higher incidence of PROM was associated with clinical characteristics in the early-onset PVL group. No significant intergroup differ�ences were observed in neurodevelopmental outcomes; however, the Bayley Scales of Infant Development-III scores were lower in the early-onset PVL group.
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