지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 113 - 119 (7page)
이용수
초록· 키워드
오류제보하기
ObjectiveAmple evidence has suggested that age at onset of Parkinson’s disease (PD) is associated with heterogeneous clinical features in individuals. We hypothesized that this may be attributed to different patterns of nigrostriatal dopamine loss. MethodsA total of 205 consecutive patients with de novo PD who underwent 18F-FP-CIT PET scans (mean follow-up duration, 6.31 years) were divided into three tertile groups according to their age at onset of parkinsonian motor symptoms. Striatal dopamine transporter (DAT) availability was compared between the old- (n = 73) and young-onset (n = 66) groups. In addition, the risk of developing freezing of gait (FOG) and longitudinal requirements for dopaminergic medications were examined. ResultsThe old-onset PD group (mean age at onset, 72.66 years) exhibited more severe parkinsonian motor signs than the young-onset group (52.58 years), despite comparable DAT availability in the posterior putamen; moreover, the old-onset group exhibited more severely decreased DAT availability in the caudate than the young-onset group. A Cox regression model revealed that the old-onset PD group had a higher risk for developing FOG than the young-onset group [hazard ratio 2.523, 95% confidence interval (1.239–5.140)]. The old-onset group required higher doses of dopaminergic medications for symptom control than the young-onset group over time. ConclusionThe present study demonstrated that the old-onset PD group exhibited more severe dopamine loss in the caudate and were more likely to develop gait freezing, suggesting that age at onset may be one of the major determinants of the pattern of striatal dopamine depletion and progression of gait disturbance in PD.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Thenganatt MA / 2014 / Parkinson disease subtypes / JAMA Neurol 71:499~504
Sieber BA / 2014 / Prioritized research recommendations from the National Institute of Neurological Disorders and Stroke Parkinson’s Disease 2014 conference / Ann Neurol 76:469~472
Fereshtehnejad SM / 2017 / Clinical criteria for subtyping Parkinson’s disease: biomarkers and longitudinal progression / Brain 140:1959~1976
Rooden SM / 2010 / The identification of Parkinson’s disease subtypes using cluster analysis: a systematic review / Mov Disord 25:969~978
Wickremaratchi MM / 2009 / The effect of onset age on the clinical features of Parkinson’s disease / Eur J Neurol 16:450~456
Sieber BA / 2014 / Prioritized research recommendations from the National Institute of Neurological Disorders and Stroke Parkinson’s Disease 2014 conference / Ann Neurol 76:469~472
Fereshtehnejad SM / 2017 / Clinical criteria for subtyping Parkinson’s disease: biomarkers and longitudinal progression / Brain 140:1959~1976
Rooden SM / 2010 / The identification of Parkinson’s disease subtypes using cluster analysis: a systematic review / Mov Disord 25:969~978
Wickremaratchi MM / 2009 / The effect of onset age on the clinical features of Parkinson’s disease / Eur J Neurol 16:450~456
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
조기 발병과 후기 발병 공황장애의 임상적 특징 비교 : 예비 연구
노인정신의학
2015 .01
-
Younger-Onset Diabetes: Is the Age of Onset More Important than the Duration of Diabetes?
Endocrinology and Metabolism
2024 .02
-
The Prevalence and Risk Factors of Atopic Dermatitis and Clinical Characteristics according to Disease Onset in 19-Year-Old Korean Male Subjects
Annals of Dermatology
2018 .01
-
Epidemiological Patterns for Early Onset and Late Onset Bacteremia after Trauma
대한외과학회 학술대회 초록집
2018 .11
-
범법 조현병 환자에서 발병연령에 따른 범죄인구특성과 대인관계문제 및 성격장애의 차이
생물치료정신의학
2018 .10
-
후기 발생 조증 환자의 정신병리와 임상적 특징 : 후향적 의무기록 조사 연구
생물치료정신의학
2015 .02
-
Comparison of Age of Onset and Frequency of Diabetic Complications in the Very Elderly Patients with Type 2 Diabetes
Endocrinology and Metabolism
2016 .01
-
Clinical Features of Atopic Dermatitis in Adults Are Different according to Onset
Journal of Korean Medical Science
2017 .01
-
Facial-Onset Sensory Motor Neuronopathy Syndrome is not Always Facial Onset
Journal of Clinical Neurology
2020 .01
-
Case 7: An 18-Year-Old Man With Sudden Onset Dyspnea
Journal of Korean Medical Science
2023 .02
-
A study to compare maternal and perinatal outcome in early vs. late onset preeclampsia
Obstetrics & Gynecology Science
2020 .01
-
Clinical spectrum of elderly-onset inflammatory bowel disease in India
Intestinal research
2023 .04
-
Dementia-Free Survival and Risk Factors for Dementia in a Hospital-Based Korean Parkinson’s Disease Cohort
Journal of Clinical Neurology
2017 .01
-
Recurrent Stroke as the Clinical Onset of POEMS Syndrome
Journal of Clinical Neurology
2017 .01
-
https://doi.org/10.3988/jcn.2019.15.1.97
Journal of Clinical Neurology
2019 .01
-
Accuracy and Reliability of Subjective Answer about Age of Onset in Psoriasis
Annals of Dermatology
2018 .01
-
Very early onset inflammatory bowel disease in a South Asian country where inflammatory bowel disease is emerging: a distinct clinical phenotype from later onset disease
Intestinal research
2021 .10
-
Adult-Onset Alexander Disease With Late-Presenting Vestibulopathy: A Case Report
Journal Of Movement Disorders
2024 .07
-
Is the Long-term Disease Course of Elderly-Onset Ulcerative Colitis Different from That of Non-Elderly-Onset Ulcerative Colitis?
Gut and Liver
2021 .09
-
Worse Renal Presentation and Prognosis in Initial-Onset Lupus Nephritis than Early-Onset Lupus Nephritis
Yonsei Medical Journal
2020 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0