Parathyroid Cancer: Comparison with Benign Hyperparathyroidism

석재연; 이준협; 이시훈; 정유승; 강석하

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자료유형: 학술저널

저자정보: 석재연 이준협 이시훈 정유승 강석하

저널정보: 대한갑상선-내분비외과학회 The Journal of Endocrine Surgery The Journal of Endocrine Surgery 제19권 제2호

발행연도: 2019.1

수록면: 35 - 44 (10page)

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연구주제

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연구배경

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연구방법

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Purpose: The preoperative diagnosis of parathyroid cancer (PC) is challenging. The purpose of this study was to identify the differences between PC and benign primary hyperparathyroidism. Methods: The medical records of 85 hyperparathyroidism patients that underwent surgery between 2001 and 2017 were retrospectively reviewed. Results: Seven of the 85 were diagnosed with PC. Mean age was 53.0±13.0 years and 66 (77.6%) were women. Follow-up duration was 52.9±44.4 months. Tumors were larger (3.50±1.26 cm vs. 2.10±0.84 cm, P=0.002), and intact parathyroid hormone (iPTH) (1,142.8±524.5 pg/mL vs. 461.2±513.5 pg/mL, P=0.002) and alkaline phosphatase (ALP) (398.6±493.6 U/L vs. 166.7±181.1 U/L, P=0.01) levels were higher in cancer patients than in benign primary hyperparathyroidism. Intraoperatively, adhesion to surrounding soft tissue or the thyroid gland was detected more frequently in cancer (85.7% vs. 12.8%, P<0.001). Two patients experienced recurrences and one of them died from PC. Conclusion: PC patients had larger tumors size, and higher serum iPTH and ALP levels. Intraoperative detection of adhesion to surrounding soft tissue/thyroid importantly raised suspicion of PC. Surgeons operating for hyperparathyroidism should be prepared to perform an appropriate en bloc resection initially upon suspicion of PC.

참고문헌 (30)

참고문헌 신청

Townsend CM Jr / 2017 / Sabiston Textbook of Surgery: the Biological Basis of Modern Surgical Practice / Elsevier Saunders

Korea Central Cancer Registry / 2017 / Annual Report of Cancer Statistics in Korea in 2015

Lloyd RV / 2017 / World Health Organization; International Agency for Research on Cancer. WHO Classification of Tumours of Endocrine Organs / International Agency for Research on Cancer

Al-Kurd A / 2014 / Parathyroid carcinoma / Surg Oncol 23:107~114

Owen RP / 2011 / Parathyroid carcinoma : a review / Head Neck 33:429~436

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