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논문 기본 정보

자료유형
학술저널
저자정보
Zahra F. Khan (University of Miami Leonard M. Miller School of Medicine Miami FL USA) John I. Lew (Division of Endocrine Surgery The DeWitt Daughtry Family Department of Surgery University of Miami)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.34 No.4
발행연도
2019.1
수록면
327 - 339 (13page)

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초록· 키워드

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Intraoperative parathyroid hormone monitoring (IPM) has been shown to be a useful adjunct during parathyroidectomy to ensureoperative success at many specialized medical centers worldwide. Using the Miami or “>50% intraoperative PTH drop” criterion,IPM confirms the complete excision of all hyperfunctioning parathyroid tissue before the operation is finished, and helps guide thesurgeon to identify additional hyperfunctioning parathyroid glands that may necessitate further extensive neck exploration when intraoperative parathyroid hormone (PTH) levels do not drop sufficiently. The intraoperative PTH assay is also used to differentiateparathyroid from non-parathyroid tissues during operations using fine needle aspiration samples and to lateralize the side of the neckharboring the hypersecreting parathyroid through differential jugular venous sampling when preoperative localization studies arenegative or equivocal. The use of IPM underscores the recognition and understanding of sporadic primary hyperparathyroidism(SPHPT) as a disease of function rather than form, where the surgeon is better equipped to treat such patients with quantitative instead of qualitative information for durable long-term operative success. There has been a significant paradigm shift over the last 2decades from conventional to focused parathyroidectomy guided by IPM. This approach has proven to be a safe and rapid operationrequiring minimal dissection performed in an ambulatory setting for the treatment of SPHPT.

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