Albumin-Bilirubin Score Predicts Tolerability to Adjuvant S-1 Monotherapy after Curative Gastrectomy

Takashi Miwa; Mitsuro Kanda; Chie Tanaka; Daisuke Kobayashi; Masamichi Hayashi; Suguru Yamada; Goro Nakayama; Masahiko Koike; Yasuhiro Kodera

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자료유형: 학술저널

저자정보: Takashi Miwa Mitsuro Kanda Chie Tanaka Daisuke Kobayashi Masamichi Hayashi Suguru Yamada Goro Nakayama Masahiko Koike Yasuhiro Kodera

저널정보: 대한위암학회 Journal of Gastric Cancer Journal of Gastric Cancer 제19권 제2호

발행연도: 2019.1

수록면: 183 - 192 (10page)

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Purpose: Due to adverse events, dose reduction or withdrawal of adjuvant chemotherapy is required for some patients. To identify the predictive factors for tolerability to postoperative adjuvant S-1 monotherapy in gastric cancer (GC) patients, we evaluated the predictive values of blood indicators. Materials and Methods: We analyzed 98 patients with pStage II/III GC who underwent postoperative adjuvant S-1 monotherapy. We retrospectively analyzed correlations between 14 parameters obtained from perioperative routine blood tests to assess their influence on the withdrawal of postoperative adjuvant S-1 monotherapy, within 6 months after discontinuation. Results: Postoperative adjuvant chemotherapy was discontinued in 21 patients (21.4%) within 6 months. Univariable analysis revealed that high preoperative albumin-bilirubin (ALBI) scores had the highest odds ratio (OR) for predicting the failure of adjuvant S-1 chemotherapy (OR, 6.47; 95% confidence interval [CI], 2.08–20.1; cutoff value, –2.696). The high ALBI group had a significantly shorter time to failure of postoperative adjuvant S-1monotherapy (hazard ratio, 3.48; 95% CI, 1.69–7.25; P=0.001). Multivariable analysis identified high preoperative ALBI score as an independent prognostic factor for tolerability (OR, 10.3; 95% CI, 2.33–45.8; P=0.002). Conclusions: Preoperative ALBI shows promise as an indicator associated with the tolerability of adjuvant S-1 monotherapy in patients with pStage II/III GC.

참고문헌 (23)

참고문헌 신청

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