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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.10
- 수록면
- 403 - 412 (10page)
이용수
초록· 키워드
오류제보하기
Curcumin, a hydrophobic polyphenol isolated from the Curcuma longa L. plant, has many pharmacological properties, including antioxidant, anti-inflammatory, and chemo-preventive activities. Curcumin has been shown to have potential in preventing nonalcoholic fatty liver disease (NAFLD). However, the low bioavailability of curcumin has proven to be a major limiting factor in its clinical adoption. Theracurmin, a highly bioavailable curcumin that utilizes micronized technology showed improved biological absorbability in vivo. The aim of this study was to investigate the role of theracurmin in modulating hepatic lipid metabolism in vivo. A fatty liver mouse model was produced by feeding mice a high fat diet (HFD; 60% fat) for 12 weeks. We found that treatment for 12 weeks with theracurmin significantly lowered plasma triacylglycerol (TG) levels and reduced HFD-induced liver fat accumulation. Theracurmin treatment lowered hepatic TG and total cholesterol (T-CHO) levels in HFD-fed mice compared to controls. In addition, theracurmin administration significantly reduced lipid peroxidation and cellular damage caused by reactive oxygen species in HFD-fed mice. Overall, these results suggest that theracurmin has the ability to control lipid metabolism and can potentially serve as an effective therapeutic remedy for the prevention of fatty liver.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (34)
참고문헌 신청
Browning, J.D. / 2004 / Molecular mediators of hepatic steatosis and liver injury / J. Clin. Invest 114:147~152
Friedman, S. L. / 2018 / Mechanisms of NAFLD development and therapeutic strategies / Nat. Med 24:908~922
Birkenfeld, A.L. / 2014 / Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes / Hepatology 59:713~723
Marra, F. / 2008 / Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis / Trends Mol. Med 14:72~81
Kotronen, A. / 2008 / Fatty liver: a novel component of the metabolic syndrome / Arterioscler. Thromb. Vasc. Biol 28:27~38
Friedman, S. L. / 2018 / Mechanisms of NAFLD development and therapeutic strategies / Nat. Med 24:908~922
Birkenfeld, A.L. / 2014 / Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes / Hepatology 59:713~723
Marra, F. / 2008 / Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis / Trends Mol. Med 14:72~81
Kotronen, A. / 2008 / Fatty liver: a novel component of the metabolic syndrome / Arterioscler. Thromb. Vasc. Biol 28:27~38
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